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Titolo:
Effects of STN lesions on simple vs choice reaction time tasks in the rat:preserved motor readiness, but impaired response selection
Autore:
Baunez, C; Humby, T; Eagle, DM; Ryan, LJ; Dunnett, SB; Robbins, TW;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England Oregon State Univ, Dept Psychol, Corvallis, OR 97331 USA Oregon State Univ Corvallis OR USA 97331 Psychol, Corvallis, OR 97331 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 8, volume: 13, anno: 2001,
pagine: 1609 - 1616
SICI:
0953-816X(200104)13:8<1609:EOSLOS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
STRIATAL DOPAMINE DEPLETION; SUBTHALAMIC NUCLEUS; BASAL GANGLIA; PARKINSONS-DISEASE; GLOBUS-PALLIDUS; CORTICAL INPUTS; PERFORMANCE; STIMULATION; INDUCE; DEFICITS;
Keywords:
basal ganglia; choice reaction time; cognition; motor programming; motor readiness; simple reaction time;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Baunez, C CNRS, Lab Neurobiol Cellulaire & Fonct, 31 Chemin Joseph Aiguier, F-13402 Marseille 20, France CNRS 31 Chemin Joseph Aiguier Marseille France 20 le 20, France
Citazione:
C. Baunez et al., "Effects of STN lesions on simple vs choice reaction time tasks in the rat:preserved motor readiness, but impaired response selection", EUR J NEURO, 13(8), 2001, pp. 1609-1616

Abstract

The subthalamic nucleus (STN) is a key structure within the basal ganglia,inactivation of which is a current strategy for treating parkinsonism. We have previously shown that bilateral lesions of the STN or pharmacological inactivation of this structure in the rat induce multiple deficits in serial reaction time tasks. The aim of the present study was to investigate further a possible role for the STN in response preparatory processes by using simple (SRT) and choice (CRT) reaction time tasks. In contrast to the CRT procedure, the information related to the location of where the response hadto be made was given in advance in the SRT procedure. Accurate performanceon these tasks requires not only the selection of the correct response (i.e. which response), but also preparation in order to perform when required. A comparison between the two tasks allows assessment of whether STN lesions affect which response ('which') or when to perform it ('when'). As previously observed in these procedures, the responses were faster as a function of the variable foreperiod preceding the trigger stimulus. This well-known effect, termed 'motor readiness', was maintained after STN lesions, suggesting that STN lesions did not affect the 'when' phase of action preparation. However, while performance on the SRT was faster than on the CRT task preoperatively, STN lesions slowed RTs and abolished the beneficial effect of advance information, suggesting a deficit in the selection ('which') phase of response preparation. This deficit in the selection phase was further supported by deficits in accuracy of responding after STN lesions, as well as increases in mislocated premature responding in the SRT condition. Together, these results suggest that the STN plays an important role in response preparatory processes, including response selection and inhibitory control processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:54:57