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Titolo:
Diffusion-weighted magnetic resonance imaging in two patients with polycythemia rubra vera and early ischemic stroke
Autore:
Koennecke, HC; Bernarding, J;
Indirizzi:
Univ Klinikum Benjamin Franklin, Dept Neurol, Stroke Unit, Berlin, GermanyUniv Klinikum Benjamin Franklin Berlin Germany ke Unit, Berlin, Germany Univ Klinikum Benjamin Franklin, Dept Med Informat, Berlin, Germany Univ Klinikum Benjamin Franklin Berlin Germany nformat, Berlin, Germany Univ Klinikum Benjamin Franklin, Dept Radiol, Berlin, Germany Univ Klinikum Benjamin Franklin Berlin Germany Radiol, Berlin, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 273 - 277
SICI:
1351-5101(200105)8:3<273:DMRIIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRANIAL DOPPLER; INFARCTION; MRI; EMBOLISM; SIGNALS; CT;
Keywords:
cerebral embolism; diffusion-weighted imaging; ischemic stroke; magnetic resonance imaging; polycythemia rubra vera;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Koennecke, HC Evangel Krankenhaus Konigin Elisabeth, Dept Neurol, Herzbergstr 79, D-10365 Berlin, Germany Evangel Krankenhaus Konigin Elisabeth Herzbergstr 79 Berlin Germany D-10365
Citazione:
H.C. Koennecke e J. Bernarding, "Diffusion-weighted magnetic resonance imaging in two patients with polycythemia rubra vera and early ischemic stroke", EUR J NEUR, 8(3), 2001, pp. 273-277

Abstract

Polycythemia rubra vera (PRV) is a rare myeloproliferative disorder with ahigh risk of ischemic stroke. Although thrombosis of large cerebral arteries is the most frequently presumed pathomechanism, various infarct patternshave been described in patients with PRV and ischemic stroke. We report two patients with mild acute ischemic strokes and known PRV, in whom a scattered lesion pattern was detected by diffusion-weighted magnetic resonance imaging (DWI), but was not visible on computed tomography (CT) and conventional magnetic resonance imaging (MRI). Further diagnostic work-up including extra- and transcranial Doppler sonography (ECD, TCD), transesophageal echocardiography (TEE), magnetic resonance angiography and Holter monitoring revealed no obvious sources of cerebral embolism in both cases. However, TEE in one patient demonstrated spontaneous echo contrast (SEC) in the left atrium. In both patients the symptomatology resolved completely. The detection of a scattered infarct pattern by DWI in patients with PRV and acute ischemic stroke has not been reported previously. DWI findings together with the SEC in one patient emphasize the assumption that a prothrombotic state withsubsequent arterial embolism rather than local arterial thrombosis may be the underlying pathomechanism of stroke in some patients with PRV. Adding DWI to the diagnostic work-up may help to clarify etiology in patients with PRV and acute ischemic stroke.

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Documento generato il 07/04/20 alle ore 21:07:44