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Titolo:
Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura
Autore:
Gervil, M; Ulrich, V; Kaprio, J; Russell, MB;
Indirizzi:
Univ Copenhagen, Glostrup Hosp, Dept Neurol, DK-2600 Glostrup, Denmark Univ Copenhagen Glostrup Denmark DK-2600 urol, DK-2600 Glostrup, Denmark Univ Helsinki, Dept Publ Hlth, FIN-00014 Helsinki, Finland Univ Helsinki Helsinki Finland FIN-00014 th, FIN-00014 Helsinki, Finland Univ Oulu, Dept Publ Hlth & Gen Practice, Oulu, Finland Univ Oulu Oulu Finland lu, Dept Publ Hlth & Gen Practice, Oulu, Finland
Titolo Testata:
EUROPEAN JOURNAL OF NEUROLOGY
fascicolo: 3, volume: 8, anno: 2001,
pagine: 231 - 235
SICI:
1351-5101(200105)8:3<231:ITGLIM>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMIPLEGIC MIGRAINE; GENERAL-POPULATION; QUESTIONNAIRE; ZYGOSITY; LOCUS; MAPS;
Keywords:
genetic liability; migraine without aura; monozygotic twins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Gervil, M Univ Copenhagen, Glostrup Hosp, Dept Neurol, DK-2600 Copenhagen,Denmark Univ Copenhagen Copenhagen Denmark DK-2600 Copenhagen, Denmark
Citazione:
M. Gervil et al., "Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura", EUR J NEUR, 8(3), 2001, pp. 231-235

Abstract

Migraine without aura (MO) is a multifactorial disorder. Expression of a disorder with multifactorial inheritance depends on the genetic liability and on environmental factors. A high liability is reflected by a high frequency of affected relatives. We have previously shown that monozygotic (MZ) twin pairs have a significant higher concordance of MO than dizygotic twin pairs. The incomplete concordance among MZ twin pairs may be due to a lower genetic liability among discordant than concordant MZ twin pairs. The present study analysed the genetic liability in MZ twin pairs concordant and discordant for MO by the population-relative risk of MO among parents and siblings. The twin pairs were from the population-based Danish Twin Register. First-degree relatives of 29 concordant and 34 discordant MZ twin pairs were blindly telephone interviewed by a physician. The participation rate of the eligible first-degree relatives was 96%. The population-relative risk of MO among parents and siblings was 2.73 (2.39-3.06) in concordant and 2.37 (2.03-2.71) in discordant MZ twin pairs. The relative risk of MO was significantly higher in female first-degree relatives of concordant than of discordant MZ male and female twin pairs. An opposite effect was observed in male first-degree relatives, although this wasnot significant for male first-degree relatives of female MZ twin pairs. The present study found no statistically significant difference in geneticliability to MO among concordant and discordant MZ twin pairs. However, a difference in genetic liability among MZ and DZ twin pairs is anticipated to be small. Thus, it may be possible to show the effect in a larger study population or by investigating a more frequent trait than MO.

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Documento generato il 28/03/20 alle ore 22:59:28