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Titolo:
Phenoxybenzamine is more effective and less harmful than papaverine in theprevention of radial artery vasospasm
Autore:
Dipp, MA; Nye, PCG; Taggart, DP;
Indirizzi:
John Radcliffe Hosp, Oxford Heart Ctr, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Ctr, Oxford OX3 9DU, England Univ Oxford, Physiol Lab, Oxford OX1 3PT, England Univ Oxford Oxford England OX1 3PT Physiol Lab, Oxford OX1 3PT, England
Titolo Testata:
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
fascicolo: 4, volume: 19, anno: 2001,
pagine: 482 - 486
SICI:
1010-7940(200104)19:4<482:PIMEAL>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROGLYCERIN SOLUTION; ENDOTHELIAL-CELLS; VERAPAMIL;
Keywords:
radial; vasospasm; phenoxybenzamine; papaverine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Taggart, DP John Radcliffe Hosp, Oxford Heart Ctr, Oxford OX3 9DU, EnglandJohn Radcliffe Hosp Oxford England OX3 9DU OX3 9DU, England
Citazione:
M.A. Dipp et al., "Phenoxybenzamine is more effective and less harmful than papaverine in theprevention of radial artery vasospasm", EUR J CAR-T, 19(4), 2001, pp. 482-486

Abstract

Objectives: There is an increasing use of arterial conduits for coronary artery bypass grafting, and the radial artery is commonly used as the third graft. The major drawback of the radial artery is its proclivity to spasm. Both papaverine and phenoxybenzamine have been recommended as topical vasodilators in clinical practice. We compared the efficacy of both drugs to prevent radial artery spasm and their ability to preserve endothelial function. Methods: The ability of both drugs to prevent alpha-adrenoreceptor mediated constriction was tested in vitro in an organ bath in radial artery segments obtained from 20 patients. Vessel viability was determined hy potassium(K+) constriction, and endothelial function was assessed by observing endothelium-dependent relaxation by a synthetic analogue of acetylcholine, carbachol., Results: Papaverine consistently abolished and prevented spasm for up to a maximum of 30 min in all segments. In contrast, phenoxybenzamine consistently abolished and prevented radial artery spasm in all segments for at least 6 h. Whereas papaverine damaged the endothelium of 70% of vessels,there was no evidence of endothelial damage in any arterial segments afterexposure to phenoxybenzamine. Conclusions: Phenoxybenzamine more effectively prevents alpha-adrenoreceptor mediated spasm of the human radial artery than papaverine. It is also less harmful to the endothelium. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 19:09:47