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Titolo:
MEAN GENES AND THE BIOLOGY OF AGGRESSION - A CRITICAL-REVIEW OF RECENT ANIMAL AND HUMAN RESEARCH
Autore:
BALABAN E; ALPER JS; KASAMON YL;
Indirizzi:
INST NEUROSCI,10640 JOHN JAY HOPKINS DR SAN DIEGO CA 92121 HARVARD UNIV,DEPT ORGANISM & EVOLUTIONARY BIOL CAMBRIDGE MA 02138 UNIV MASSACHUSETTS,DEPT CHEM BOSTON MA 02125 UNIV MASSACHUSETTS,CTR GENET & PUBL POLICY BOSTON MA 02125
Titolo Testata:
Journal of neurogenetics
fascicolo: 1-2, volume: 11, anno: 1996,
pagine: 1 - 43
SICI:
0167-7063(1996)11:1-2<1:MGATBO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID MONOAMINE; 5-HYDROXYINDOLEACETIC ACID LEVELS; CSF-AMINE METABOLITES; CALMODULIN KINASE-II; CENTRAL SEROTONERGIC SYSTEM; IMPULSIVE FIRE SETTERS; NITRIC-OXIDE SYNTHASE; HEALTHY-VOLUNTEERS; DEPRESSED-PATIENTS; SUICIDAL-BEHAVIOR;
Keywords:
PSYCHIATRY; IMPULSIVE BEHAVIOR; VIOLENT BEHAVIOR; SEROTONIN; 5-HIAA; METAANALYSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
161
Recensione:
Indirizzi per estratti:
Citazione:
E. Balaban et al., "MEAN GENES AND THE BIOLOGY OF AGGRESSION - A CRITICAL-REVIEW OF RECENT ANIMAL AND HUMAN RESEARCH", Journal of neurogenetics, 11(1-2), 1996, pp. 1-43

Abstract

Recent genetic work has suggested that abnormalities in serotonin biochemistry are directly causally linked to aggressive behavior, and there appears to be a consensus in the psychiatric literature that low levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid are specifically associated with impulsive violent behavior. We review the limitations of the genetic studies and conduct a meta-analysis of 39 studies Linking 5-HIAA to aggression in humans. No differences in mean 5-HIAA levels were found between groups of violent impulsive psychiatric patients and groups of subjects diagnosed with other psychiatric or medical conditions not considered to involve violence once these levels had been corrected for three nonpsychiatric sources of variation (age, sex and height). However, mean 5-HIAA levels in both of these groups were lower than the mean corrected levelin groups of normal healthy volunteers. The results confirm an association between low 5-HIAA levels and psychiatric disorders, but fail tosupport any specific relationship between low 5-HIAA levels and impulsive aggression or criminality. It is premature and misleading to speak of ''mean genes'' (Hen 1996) or a specific neurochemistry of aggressive behavior.

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Documento generato il 13/07/20 alle ore 04:27:33