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Titolo:
DNA adducts of 1,3-butadiene in humans: Relationships to exposure, GST genotypes, single-strand breaks, and cytogenetic end points
Autore:
Zhao, C; Vodicka, P; Sram, RJ; Hemminki, K;
Indirizzi:
Karolinska Inst, Novum, Ctr Nutr & Toxicol, Dept Biosci, S-14157 Huddinge,Sweden Karolinska Inst Huddinge Sweden S-14157 Biosci, S-14157 Huddinge,Sweden Acad Sci Czech Republ, Inst Expt Med, Prague, Czech Republic Acad Sci Czech Republ Prague Czech Republic Med, Prague, Czech Republic
Titolo Testata:
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
fascicolo: 3, volume: 37, anno: 2001,
pagine: 226 - 230
SICI:
0893-6692(2001)37:3<226:DAO1IH>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFERASE M1 GENOTYPE; GENETIC-POLYMORPHISM; OCCUPATIONAL EXPOSURE; HUMAN-LYMPHOCYTES; BLOOD-CELLS; LUNG-CANCER; WORKERS; CYP1A1; BUTADIENE; INDUCTION;
Keywords:
N-1-(2,3,4-trihydroxybutyl)adenine; 1,3-butadiene; human; genotype; cytogenetic end points;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, C Karolinska Inst, Novum, Ctr Nutr & Toxicol, Dept Biosci, S-14157 Huddinge,Sweden Karolinska Inst Huddinge Sweden S-14157 S-14157 Huddinge,Sweden
Citazione:
C. Zhao et al., "DNA adducts of 1,3-butadiene in humans: Relationships to exposure, GST genotypes, single-strand breaks, and cytogenetic end points", ENV MOL MUT, 37(3), 2001, pp. 226-230

Abstract

The modulation of 1,3-butadiene (BD)-induced DNA adducts by occupational exposure, glutathione S-transferase (GST) genotypes, single-strand breaks, and cytogenetic end points was studied in 15 workers and 11 controls. The exposed group consisted of 8 smokers and 7 nonsmokers, whereas the control group consisted of 7 nonsmokers and 4 smokers. Among all subjects, the adductlevels in workers lacking GSTM1 were significantly higher than in those who were GSTM1 positive (P = 0.026), and individuals with combined GSTM1(-) and GSTT1(+) genotype had elevated level of adducts compared to that of persons with GSTM1(+) and GSTT1(+) (P = 0.049). The increase in BD-DNA adduct levels in all subjects was significantly related to BD exposure and GSTM1 genotype (linear multiple regression analysis, P = 0.001; P = 0.035). The results suggest that DNA adducts serve as a sensitive and specific biomarker, integrating exposure and host metabolic capacity, although the data are limited to a small number of subjects. Environ. Mol. Mutagen. 37: 226-230, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/05/20 alle ore 04:06:21