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Titolo:
Endothelin-1 plasma concentration increases in the early phase of pulmonary hypertension development during respiratory distress syndrome: a study innewborn lambs
Autore:
de Vroomen, M; Cardozo, RHL; Steendijk, P; Frolich, M; Baan, J; van Bel, F;
Indirizzi:
Univ Utrecht, Med Ctr, Wilhelmina Childrens Hosp, Dept Neonatol, NL-3508 AB Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 AB 3508 AB Utrecht, Netherlands Leiden Univ, Med Ctr, Dept Cardiol C5P, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Med Ctr, Dept Pediat J6, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands Leiden Univ, Med Ctr, Dept Clin Chem L2, NL-2300 RC Leiden, Netherlands Leiden Univ Leiden Netherlands NL-2300 RC NL-2300 RC Leiden, Netherlands
Titolo Testata:
EARLY HUMAN DEVELOPMENT
fascicolo: 1, volume: 63, anno: 2001,
pagine: 9 - 21
SICI:
0378-3782(200106)63:1<9:EPCIIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGENITAL HEART-DEFECTS; CIRCULATION; DISEASE; CELLS; TONE;
Keywords:
endothelins; hemodynamics; pulmonary circulation; vasoconstriction/dilation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: van Bel, F Univ Utrecht, Med Ctr, Wilhelmina Childrens Hosp, Dept Neonatol, Room KE 04-123-1,POB 85090, NL-3508 AB Utrecht, Netherlands Univ Utrecht Room KE 04-123-1,POB 85090 Utrecht Netherlands NL-3508 AB
Citazione:
M. de Vroomen et al., "Endothelin-1 plasma concentration increases in the early phase of pulmonary hypertension development during respiratory distress syndrome: a study innewborn lambs", EAR HUM DEV, 63(1), 2001, pp. 9-21

Abstract

Elevated plasma concentrations of endothelin-1 (ET-1) have been reported with pulmonary hypertension during respiratory distress syndrome (RDS). However, the exact role of ET-1 in the development of pulmonary hypertension during RDS is unclear. The relative time-course of changes in ET-1 concentrations and pulmonary artery pressure (P-ap) during RDS may give insight in the role of ET-1. Methods: ET-1 and P-ap changes were studied in an experimental model of RDS, induced by lung lavages in seven newborn lambs. Five other lambs served as controls. Results: Lung lavages induced a twofold increase of mean P-ap (from 15 to 34 mm Hg) that remained present throughout the 4-h study period. Along withthe increased P-ap, ET-1 plasma concentration showed a significant increase 15 min after induction of RDS at all three sample locations (pulmonary artery 198%, aorta 181% and right atrium 195% compared to baseline). This increased concentration remained high at 1 and 4 h of RDS. In control animals,no significant changes in ET-1 concentrations were observed. Plotting ET-1concentration values against mean P-ap, in RDS and control animals at all time points, a correlation was found between the severity of the pulmonary hypertension and ET-1 concentration. Conclusion: This experimental model of RDS shows that ET-I concentration increases concomitant with the development of pulmonary hypertension, from an early time point onward. More severe pulmonary hypertension is associatedwith higher ET-I concentrations, but whether ET-1 is a marker or a mediator of pulmonary hypertension remains as yet unsettled. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 03:23:13