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Titolo:
TACE and other ADAM proteases as targets for drug discovery
Autore:
Moss, ML; White, JM; Lambert, MH; Andrews, RC;
Indirizzi:
Cognosci, Res Triangle Pk, NC 27709 USA Cognosci Res Triangle Pk NC USA 27709 osci, Res Triangle Pk, NC 27709 USA Uva Hlth Syst Sch Med, Dept Cell Biol, Charlottesville, VA USA Uva Hlth Syst Sch Med Charlottesville VA USA ol, Charlottesville, VA USA Glaxo SmithKline, Res Triangle Pk, NC USA Glaxo SmithKline Res Triangle Pk NC USA thKline, Res Triangle Pk, NC USA
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 8, volume: 6, anno: 2001,
pagine: 417 - 426
SICI:
1359-6446(20010415)6:8<417:TAOAPA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; AMYLOID PRECURSOR PROTEIN; MATRIX METALLOPROTEINASE INHIBITOR; ANGIOTENSIN-CONVERTING ENZYME; TRANS-GOLGI NETWORK; BETA-SECRETASE; GROWTH-FACTOR; DISINTEGRIN-METALLOPROTEASE; ALZHEIMERS-DISEASE; GAMMA-SECRETASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Moss, ML Cognosci, 2 Davis Dr,POB 12076, Res Triangle Pk, NC 27709 USA Cognosci 2 Davis Dr,POB 12076 Res Triangle Pk NC USA 27709 09 USA
Citazione:
M.L. Moss et al., "TACE and other ADAM proteases as targets for drug discovery", DRUG DISC T, 6(8), 2001, pp. 417-426

Abstract

Tumor necrosis factor (TNF)-converting enzyme (TACE) and other ADAM proteases (those that contain a disintegrin and a metalloprotease domain) have emerged as potential therapeutic targets in the areas of arthritis, cancer, diabetes and HIV cachexia. TACE is the first ADAM protease to process the known physiological substrate and inflammatory cytokine, membrane-bound precursor-TNF-a, to its mature soluble form. Subsequently, TACE was shown to be required for several different processing events such as tumor growth factor-alpha (TGF-alpha) precursor and amyloid precursor protein (APP) cleavage. With the recent discoveries of the proteolytic specificities of other ADAMfamily members, the information surrounding these metalloproteases is expanding at an exponential rate. This review focuses on TACE and other family members with known proteolytic function as well as the inhibitors of this class of enzyme.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 15:30:36