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Titolo:
Neuroprotection during hypoxic insults: Role of adenosine
Autore:
Sebastiao, AM; de Mendonca, A; Ribeiro, JA;
Indirizzi:
Fac Med Lisbon, Neurosci Lab, P-1649028 Lisbon, Portugal Fac Med Lisbon Lisbon Portugal P-1649028 Lab, P-1649028 Lisbon, Portugal
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 1-2, volume: 52, anno: 2001,
pagine: 291 - 295
SICI:
0272-4391(200101/02)52:1-2<291:NDHIRO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL SLICES; METABOTROPIC GLUTAMATE RECEPTORS; TRANSIENT FOREBRAIN ISCHEMIA; EXCITATORY AMINO-ACIDS; SYNAPTIC TRANSMISSION; INHIBITORY INTERNEURONS; ACETYLCHOLINE-RELEASE; ENDOGENOUS ADENOSINE; MEMBRANE-PROPERTIES; CEREBRAL-ISCHEMIA;
Keywords:
hypoxia; adenosine receptors; hippocampus; neuronal survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Sebastiao, AM Fac Med Lisbon, Neurosci Lab, Av Prof Egas Moniz, P-1649028 Lisbon, Portugal Fac Med Lisbon Av Prof Egas Moniz Lisbon Portugal P-1649028
Citazione:
A.M. Sebastiao et al., "Neuroprotection during hypoxic insults: Role of adenosine", DRUG DEV R, 52(1-2), 2001, pp. 291-295

Abstract

Adenosine is released from neurones and from glial cells during hypoxic and ischaemic episodes, and, by operating membrane A? receptors, acts as a neuroprotective agent. Evidence for this neuroprotective role of adenosine issupplied by both in vivo and in vitro studies. By evaluating the action ofhypoxia on synaptic transmission in hippocampal slices, it has been shown that substances that are also released during hypoxia, such as gamma -aminobutyric acid (GABA), acetylcholine, and even glutamate may also have a neuroprotective role; however their action is evident only when activation of adenosine A(1) receptors is impaired. We propose that adenosine A(1) receptors have a pivotal role during hypoxia, though other substances can operate in a redundant or even overprotective manner, acting as a substitute for some adenosine actions when the nucleoside is not operative. Drug Dev. Res. 52:291-295, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:05:52