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Titolo:
Study of aggregation of platelets lacking the P2Y(1) receptor
Autore:
Fabre, JE; King, BF; Koller, BH;
Indirizzi:
Univ N Carolina, Cyst Fibrosis Ctr, Dept Med, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 t Med, Chapel Hill, NC 27599 USA Royal Free & Univ Coll Med Sch, Autonom Neurosci Inst, London, England Royal Free & Univ Coll Med Sch London England sci Inst, London, England
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 1-2, volume: 52, anno: 2001,
pagine: 150 - 155
SICI:
0272-4391(200101/02)52:1-2<150:SOAOPL>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
P2X(1) RECEPTORS; BLOOD-PLATELETS; ADP RECEPTORS; CYCLIC-AMP; ACTIVATION; ATP; MICE; PURINOCEPTORS; RESISTANCE; DISTINCT;
Keywords:
platelets; purinoceptors; ADP; P2Y(1); P2Yac; thrombosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Fabre, JE Univ N Carolina, Cyst Fibrosis Ctr, Dept Med, CB 7248,Thurston Bowles Bldg, Chapel Hill, NC 27599 USA Univ N Carolina CB 7248,Thurston Bowles Bldg Chapel Hill NC USA 27599
Citazione:
J.E. Fabre et al., "Study of aggregation of platelets lacking the P2Y(1) receptor", DRUG DEV R, 52(1-2), 2001, pp. 150-155

Abstract

The recent. generation of mice deficient for the P2Y(1) receptor has allowed us to directly examine the contribution of this nucleotide receptor in ADP-induced aggregation both in isolated platelets and in vivo thrombosis. Studies utilizing the P2Y(1)-deficient platelets clearly demonstrated that the P2Y(1) receptor alone is not sufficient for describing the various effects induced by ADP on platelets. While no increase in intracellular calcium was observed in the platelets lacking P2Y(1), the ability of ADP to decrease intracellular cAMP was unaltered. An additive and unexpected observation is the partial aggregation induced by exposure of P2Y(1)-deficient platelets to high levels of ABP. This suggests that additional ADP receptors are expressed by platelets and that these receptors can induce partial aggregation of platelets in the absence of measurable changes in intracellular calcium. This review summarizes the recent advances in understanding the mechanisms involved in the platelet response to ADP and examines various hypothesesthat attempt to explain the pathway leading to partial aggregation of P2Y(1) platelets in response to ADP. Drug Dev. Res. 52:150-155, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:14:49