Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nucleoside transporter and nucleotide vesicular transporter: Two examples of mnemonic regulation
Autore:
Sen, RP; Delicado, EG; Miras-Portugal, MT; Gualix, J;
Indirizzi:
Univ Complutense Madrid, Fac Vet, Dept Bioquim, E-28040 Madrid, Spain UnivComplutense Madrid Madrid Spain E-28040 quim, E-28040 Madrid, Spain
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 1-2, volume: 52, anno: 2001,
pagine: 11 - 21
SICI:
0272-4391(200101/02)52:1-2<11:NTANVT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED CHROMAFFIN CELLS; PROTEIN-KINASE-C; ADENOSINE TRANSPORT; NITROBENZYLTHIOINOSINE BINDING; DIADENOSINE POLYPHOSPHATES; SYNAPTIC TERMINALS; URIDINE TRANSPORT; ADRENAL-MEDULLA; PHORBOL ESTERS; EPSILON-ATP;
Keywords:
ATP; diadenosine; polyphosphates; adenosine; purinergic transmission; nucleotide vesicular transport; nucleoside transport; mnemonic transporter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Sen, RP Univ Complutense Madrid, Fac Vet, Dept Bioquim, Av Puerta de Hierro S-N, E-28040 Madrid, Spain Univ Complutense Madrid Av Puerta de Hierro S-N Madrid Spain E-28040
Citazione:
R.P. Sen et al., "Nucleoside transporter and nucleotide vesicular transporter: Two examples of mnemonic regulation", DRUG DEV R, 52(1-2), 2001, pp. 11-21

Abstract

According to their relevant roles in the regulation and availability of extracellular levels of purinergic signals, the nucleoside transporter and the nucleotide vesicular transporter are subject to acute regulation. The plasma membrane nucleoside transporter has been shown to exhibit several regulatory mechanisms, such as regulation by long-term signals, phosphorylation/dephosphorylation processes, and allosteric modulation. The present work reviews studies concerning allosteric modulation of nucleoside and nucleotidevesicular transporters, as the first reported examples of mnemonic behavior in transporter proteins, presenting kinetic and allosteric cooperativity. This fact implies that the protein can exhibit different conformations, each one with specific kinetic parameters. Transport substrates are able to induce slow conformational changes between the different forms of the transporter. This kinetic mechanism can provide several physiological advantages,since it allows strict control of transport capacity by changes in substrate concentrations. This allosteric modulation has been confirmed in severalexperimental models, the nucleoside transporter in chromaffin and endothelial cells from adrenal medulla and the nucleotide vesicular transporter in the chromaffin cell granules and rat brain synaptic vesicles. Taking into account these considerations, the mnemonic regulation described here could be a widespread mechanism among transporter proteins. Drug Dev. Res. 52:11-21, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:46:10