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Titolo:
Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 (GADD45 beta) gene
Autore:
Balliet, AG; Hatton, KS; Hoffman, B; Lieberman, DA;
Indirizzi:
Temple Univ, Sch Med, Dept Biochem, Fels Inst Canc Res & Mol Biol, Philadelphia, PA 19104 USA Temple Univ Philadelphia PA USA 19104 ol Biol, Philadelphia, PA 19104 USA
Titolo Testata:
DNA AND CELL BIOLOGY
fascicolo: 4, volume: 20, anno: 2001,
pagine: 239 - 247
SICI:
1044-5498(200104)20:4<239:CAOTGS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
P53-REGULATED PROTEIN GADD45; NEGATIVE GROWTH-CONTROL; DNA-DAMAGE; CELL-GROWTH; C-MYC; FAMILY; SEQUENCES; INTERACTS; RESPONSES; CLONING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hoffman, B Temple Univ, Sch Med, Dept Biochem, Fels Inst Canc Res & Mol Biol, 3307 N Broad St, Philadelphia, PA 19104 USA Temple Univ 3307 N Broad StPhiladelphia PA USA 19104 19104 USA
Citazione:
A.G. Balliet et al., "Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 (GADD45 beta) gene", DNA CELL B, 20(4), 2001, pp. 239-247

Abstract

The MyD118 (Gadd45 beta) protein is a member of a family of structurally related proteins, including Gadd45 (Gadd45 alpha) and CR6 (Gadd45 gamma), that have critical roles in regulating growth arrest and apoptosis, The MyD118 and other members of its family display distinct patterns of expression in response to stimuli that induce differentiation, growth arrest, or apoptosis. Species-blot analysis showed that MyD118 is an evolutionarily conserved gene, and comparative sequence analysis showed that MyD118 has a gene structure similar to that of other members of its gene family. Comparison of putative transcription factor-binding sites found in sequences of this gene family provides evidence that p53 is involved in regulating the expression of MyD118 and that NF-kappaB may play a role in differential expression of MyD118 and Gadd45(Gadd45a). fluorescence in situ hybridization localized the MyD118 gene to mouse chromosome band 10B5.3, correcting a previous assignment to mouse chromosome 9.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:59:25