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Titolo:
Insulin secretion, obesity, and potential behavioral influences: results from the Insulin Resistance Atherosclerosis Study (IRAS)
Autore:
Mayer-Davis, EJ; Levin, S; Bergman, RN; DAgostino, RB; Karter, AJ; Saad, MF;
Indirizzi:
Univ S Carolina, Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 l & Biostat, Columbia, SC 29208 USA Univ So Calif, Sch Med, Dept Physiol & Biophys, Los Angeles, CA 90033 USA Univ So Calif Los Angeles CA USA 90033 Biophys, Los Angeles, CA 90033 USA Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27157 USA Wake Forest Univ Winston Salem NC USA 27157 , Winston Salem, NC 27157 USA Kaiser Permanente, Div Res, Oakland, CA 94611 USA Kaiser Permanente Oakland CA USA 94611 te, Div Res, Oakland, CA 94611 USA Univ Calif Los Angeles, Med Ctr, Div Endocrinol, Los Angeles, CA 90024 USAUniv Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 2, volume: 17, anno: 2001,
pagine: 137 - 145
SICI:
1520-7552(200103/04)17:2<137:ISOAPB>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; FIRST-DEGREE RELATIVES; GLUCOSE-TOLERANCE; PHYSICAL-ACTIVITY; CELL FUNCTION; PIMA-INDIANS; FATTY-ACIDS; BODY-WEIGHT; SENSITIVITY; MEN;
Keywords:
insulin secretion; disposition index dietary fat; physical activity; alcohol; body mass index;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Mayer-Davis, EJ Univ S Carolina, Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA Univ S Carolina Columbia SC USA 29208 umbia, SC 29208 USA
Citazione:
E.J. Mayer-Davis et al., "Insulin secretion, obesity, and potential behavioral influences: results from the Insulin Resistance Atherosclerosis Study (IRAS)", DIABET M R, 17(2), 2001, pp. 137-145

Abstract

Background This work was conducted to evaluate associations of insulin secretion with overall and central obesity, dietary fats, physical activity, and alcohol. Methods A frequently sampled intravenous glucose tolerance test (FSIGT) was used to assess acute insulin response to glucose (AIR) and insulin sensitivity (SI) among adult participants (n = 675 with normal, NGT; n = 332 withimpaired glucose tolerance, IGT) in the Insulin Resistance AtherosclerosisStudy (IRAS). Disposition index (DI) was calculated as the sum of the log-transformed AIR and SI to reflect pancreatic compensation for insulin resistance. Obesity was measured as body mass index (kg/m(2), BMI) and central fat distribution by waist circumference (cm). Dietary fat intake (total, saturated, polyunsaturated, oleic acid), physical activity, and alcohol intakewere assessed by standardized interview. Results In unadjusted analyses, BMI and waist were each positively correlated with AIR among NGTs (r = 0.26 and 0.23, respectively; p < 0.0001) but correlations were weaker among the IGTs (r = 0.10, NS; r = 0.13, p <0.05 forBMI and waist, respectively). BMI and waist were inversely correlated withDI among NGTs (r = -0.13 and -0.20, respectively; p < 0.0001) and among IGTs (r = -0.20 and -0.19, respectively, p < 0.0001). Dietary fat variables were positively related, and alcohol was inversely related, to AIR among NGTs (p < 0.01) but not among IGTs. With all factors considered simultaneouslyin a pooled analysis of IGTs and NGTs, waist, but not BMI, was positively associated with AIR (p < 0.001) and inversely associated with DI (p < 0.01). None of the behavioral variables were independently related to either outcome. Conclusion Among non-diabetic patients, central obesity appears to be related to higher insulin secretion, but to lower capacity of the pancreas to respond to the ambient insulin resistance. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:25:57