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Titolo:
Hyperfibrinogenemia and metabolic syndrome in type 2 diabetes: a population-based study
Autore:
Bruno, G; Cavallo-Perin, P; Bargero, G; Borra, M; DErrico, N; Macchia, G; Pagano, G;
Indirizzi:
Univ Turin, Dipartimento Med Interna, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 timento Med Interna, I-10126 Turin, Italy Osped Santo Spirito, Casale Monferrato, Italy Osped Santo Spirito Casale Monferrato Italy o, Casale Monferrato, Italy
Titolo Testata:
DIABETES-METABOLISM RESEARCH AND REVIEWS
fascicolo: 2, volume: 17, anno: 2001,
pagine: 124 - 130
SICI:
1520-7552(200103/04)17:2<124:HAMSIT>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; ALBUMIN EXCRETION RATE; CARDIOVASCULAR RISK-FACTORS; PLASMA-FIBRINOGEN; INSULIN-RESISTANCE; GLYCEMIC CONTROL; MYOCARDIAL-INFARCTION; HEMOSTATIC FACTORS; FACTOR-VII; MELLITUS;
Keywords:
diabetes mellitus; type 2; fibrinogen; coronary heart disease; glycemic control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Bruno, G Univ Turin, Dipartimento Med Interna, Corso Dogliotti 14, I-10126Turin, Italy Univ Turin Corso Dogliotti 14 Turin Italy I-10126 6 Turin, Italy
Citazione:
G. Bruno et al., "Hyperfibrinogenemia and metabolic syndrome in type 2 diabetes: a population-based study", DIABET M R, 17(2), 2001, pp. 124-130

Abstract

Background It has been hypothesized that fibrinogen clusters with several components of the metabolic syndrome, thus increasing its cardiovascular risk. The aims of the present study were to assess in a large population-based cohort of patients with type 2 diabetes (1) variables associated with fibrinogen and (2) the relationship between hyperfibrinogenemia, a number of components of the metabolic syndrome, and coronary heart disease (CHD). Methods We identified a cross-sectional, population-based cohort of 1574 patients with type 2 diabetes using multiple sources of ascertainment. Components of the metabolic syndrome were hypertension (systolic blood pressure greater than or equal to 160 mmHg and/or diastolic blood pressure greater than or equal to 95 mmHg and/or treatment with antihypertensive drugs), dyslipidemia (tryglicerides >2.82 mmol/l and/or HDL-cholesterol <1.03 mmol/l), hyperuricemia (uric acid > 416 mu mol/l) and increased albumin excretion rate (AER greater than or equal to 20 mug/min). Results Fibrinogen increases with age, HbA(1c), smoking, hypertension and a number of components of the metabolic syndrome, even after adjustment forconfounders. Prevalence of CHD increases linearly across quartiles of fibrinogen (from 26.1 to 40.6%, p = 0.046). However, in logistic regression, after adjustment for both confounders and known risk factors for CHD, the role of fibrinogen is no more significant, whereas ORs for HbA(1c) between 6.8and 8.8% and >8.8% vs values <6.8% are, respectively, 1.91 (95% CI 1.36-2.69) and 1.56 (1.07-2.27). Conclusions This population-based study shows that fibrinogen increases with age, HbA(1c), smoking, hypertension and a number of components of the metabolic syndrome, independent of major confounders. We also found that poorblood glucose control was associated with CHD. Copyright (C) 2000 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:57:10