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Titolo:
Macronutrients, fat mass, fatty acid flux and insulin sensitivity
Autore:
Ziegler, O; Quilliot, D; Guerci, B; Drouin, P;
Indirizzi:
Hop Jeanne dArc, Ctr Hosp Univ Nancy, Serv Diabetol Malad Metab & Nutr, F-54201 Toul, France Hop Jeanne dArc Toul France F-54201 d Metab & Nutr, F-54201 Toul, France
Titolo Testata:
DIABETES & METABOLISM
fascicolo: 2, volume: 27, anno: 2001,
parte:, 2
pagine: 261 - 270
SICI:
1262-3636(200104)27:2<261:MFMFAF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
FRE
Soggetto:
DIETARY FIBER; WEIGHT-LOSS; DIABETES-MELLITUS; GLYCEMIC LOAD; OBESITY; RESISTANCE; MANAGEMENT; RISK; MEN; MECHANISMS;
Keywords:
insulin resistance; metabolic syndrome; macronutrients; free fatty acids; abdominal obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Ziegler, O Hop Jeanne dArc, Ctr Hosp Univ Nancy, Serv Diabetol Malad Metab& Nutr, Dommartin Les Toul,BP 303, F-54201 Toul, France Hop Jeanne dArc Dommartin Les Toul,BP 303 Toul France F-54201
Citazione:
O. Ziegler et al., "Macronutrients, fat mass, fatty acid flux and insulin sensitivity", DIABETE MET, 27(2), 2001, pp. 261-270

Abstract

Obesity and visceral or upper body fat distribution, have a major impact on insulin sensitivity. There is strong evidence to suggest that free fatty acids (FFA) contribute to the pathogenesis of insulin resistance and the metabolic syndrome. Increased FFA release from adipose tissue or failure of FFA using tissues to remove them normally, lead to increased triglycerides (TG) and FFA fluxes. Increased delivery of FFA to muscle reduces muscle glucose uptake and utilisation by substrate competition or direct inhibition ofglucose transport. Insulin resistance has been correlated with the size ofintramuscular TG stare. Intracellular TG have been involved in beta cell failure the so called lipotoxicity phenomena. The rate of FFA to the liver is a major determinant of hepatic TG secretion. So the regulation of FFA distribution between FFA using tissues and the partition of FFA between storage and oxidation could be involved in the developpment of insulin resistance. The dietary macronutrients could play a role in nutrient partitioning buttheir role in the etiology of insulin resistance is poorly understood due to a paucity of credible intervention studies in humans. However deleterious effects of saturated fatty acids on insulin action and the beneficial effects of polyunsaturated fatty acids (PUFAs) could be suspected from animal studies, and from epidemiological or clinical studies in humans. A very high intake of sucrose or fructose could be deleterious but low glycemic indexfoods, and fibers could have protective effects. Weight loss can induce marked improvement in insulin resistance, but weight maintenance is also required to keep long term good metabolic results.

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Documento generato il 10/07/20 alle ore 18:26:10