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Titolo:
Ontogeny of ionotropic glutamate receptor expression in human fetal brain
Autore:
Ritter, LM; Unis, AS; Meador-Woodruff, JH;
Indirizzi:
Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 th Res Inst, Ann Arbor, MI 48109 USA Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 pt Psychiat, Ann Arbor, MI 48109 USA Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t & Behav Sci, Seattle, WA 98195 USA
Titolo Testata:
DEVELOPMENTAL BRAIN RESEARCH
fascicolo: 2, volume: 127, anno: 2001,
pagine: 123 - 133
SICI:
0165-3806(20010430)127:2<123:OOIGRE>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; D-ASPARTATE RECEPTOR; YM09151-2 BINDING-SITES; CENTRAL-NERVOUS-SYSTEM; AMINO-ACID RECEPTORS; NEURONAL MIGRATION; H-3 SCH23390; NMDA; SUBUNIT; CORTEX;
Keywords:
NMDA receptor; AMPA receptor; kainate receptor; messenger RNA; development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Meador-Woodruff, JH Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 or, MI 48109 USA
Citazione:
L.M. Ritter et al., "Ontogeny of ionotropic glutamate receptor expression in human fetal brain", DEV BRAIN R, 127(2), 2001, pp. 123-133

Abstract

Glutamate receptors have multiple roles in the central nervous system. Recent evidence suggests that the iontropic glutamate receptors are critical during brain development, particularly fur corticogenesis, neuronal migration. and synaptogenesis. In this study, we examined subunit mRNA expression and binding sites of the NMDA, AMPA, and kainate receptors from gestational weeks 8-20 in human fetal brain. Expression of glutamate receptors was highduring several periods in these brains. Different levels of expression of each NMDA, AMPA, and kainate receptor subunit transcripts were present during development, with a greater abundance of NR1, NR2B, NR2D, GluR7, and KA1mRNA at most gestational ages. Binding sites for NMDA, AMPA, and kainate receptors were all detected, but each had a unique pattern of expression. These results demonstrate that glutamate receptors are expressed early in human brain development, and undergo complex changes over time consistent withtheir role in normal development. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 11:18:35