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Titolo:
Direct regulation of the muscle-identity gene apterous by a Hox protein inthe somatic mesoderm
Autore:
Capovilla, M; Kambris, Z; Botas, J;
Indirizzi:
Inst Biol Mol & Cellulaire, CNRS, UPR 9022, F-67084 Strasbourg, France Inst Biol Mol & Cellulaire Strasbourg France F-67084 Strasbourg, France Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA Baylor CollMed Houston TX USA 77030 & Human Genet, Houston, TX 77030 USA Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cellular Biol, Houston, TX 77030 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 8, volume: 128, anno: 2001,
pagine: 1221 - 1230
SICI:
0950-1991(200104)128:8<1221:DROTMG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA-BINDING SPECIFICITY; CENTRAL-NERVOUS-SYSTEM; HOMEOTIC GENES; HOMEOBOX GENES; ULTRABITHORAX PROTEIN; MIDGUT MORPHOGENESIS; HOMEODOMAIN PROTEINS; BITHORAX COMPLEX; DROSOPHILA; PATTERN;
Keywords:
antennapedia; apterous; Drosophila; Hox; muscles;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Capovilla, M Inst Biol Mol & Cellulaire, CNRS, UPR 9022, 15 Rue Rene Descartes, F-67084Strasbourg, France Inst Biol Mol & Cellulaire 15 Rue Rene Descartes Strasbourg France F-67084
Citazione:
M. Capovilla et al., "Direct regulation of the muscle-identity gene apterous by a Hox protein inthe somatic mesoderm", DEVELOPMENT, 128(8), 2001, pp. 1221-1230

Abstract

Hox genes control segment identity in the mesoderm as well as in other tissues. Most evidence indicates that Hox genes act cell-autonomously in muscle development, although this remains a controversial issue. We show that apterous expression in the somatic mesoderm is under direct Hox control. We have identified a small enhancer element of apterous (apME680) that regulates reporter gene expression in the LT1-4 muscle progenitors. We show that the product of the Hox gene Antennapedia is present in the somatic mesoderm of the second and third thoracic segments. Through complementary alterationsin the Antennapedia protein and in its binding sites on apME680, we show that Antennapedia positively regulates apterous in a direct manner, demonstrating unambiguously its cell-autonomous role in muscle development. Finally, we determine that LT1-4 muscles contain more nuclei in the thorax than inthe abdomen and we propose that one of the segmental differences under Hoxcontrol is the number of myoblasts allocated to the formation of specific muscles in different segments.

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Documento generato il 30/11/20 alle ore 16:46:31