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Titolo:
Homocysteine and stroke
Autore:
Hankey, GJ; Eikelboom, JW;
Indirizzi:
Royal Perth Hosp, Dept Neurol, Stroke Unit, Perth, WA 6001, Australia Royal Perth Hosp Perth WA Australia 6001 Unit, Perth, WA 6001, Australia Univ Western Australia, Dept Med, Nedlands, WA 6009, Australia Univ Western Australia Nedlands WA Australia 6009 nds, WA 6009, Australia McMaster Univ, Prevent Cardiol & Therapeut Program, Hamilton, ON, Canada McMaster Univ Hamilton ON Canada Therapeut Program, Hamilton, ON, Canada
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 95 - 102
SICI:
1350-7540(200102)14:1<95:HAS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA TOTAL HOMOCYSTEINE; SMOOTH-MUSCLE CELLS; FOLIC-ACID; ENDOTHELIAL DYSFUNCTION; ISCHEMIC STROKE; METHYLENETETRAHYDROFOLATE REDUCTASE; RISK FACTOR; CAROTID ATHEROSCLEROSIS; CARDIOVASCULAR-DISEASE; GENE-EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Hankey, GJ Royal Perth Hosp, Dept Neurol, Stroke Unit, Wellington St, Perth, WA 6001,Australia Royal Perth Hosp Wellington St Perth WA Australia 6001ustralia
Citazione:
G.J. Hankey e J.W. Eikelboom, "Homocysteine and stroke", CURR OP NEU, 14(1), 2001, pp. 95-102

Abstract

During the past year epidemiological studies have linked elevated plasma total homocysteine concentrations with an increased risk of ischaemic strokebecause of arterial disease. Laboratory studies have further explored the mitogenic effects of total homocysteine on vascular smooth muscle, and cytotoxic and thrombophilic effects on vascular endothelium. Also, a clinical trial has shown that lowering total homocysteine by means of multivitamin therapy decreases the rate of abnormal exercise electrocardiography tests. However. it remains to be determined whether lowering total homocysteine prevents hard clinical outcome events, such as stroke and other serious vascular events. An alternative explanation for the observed association between elevated total homocysteine and stroke is a confounding effect of factors associated with hyperhomocysteinaemia (e.g, cigarette smoking. renal impairment. an atherogenic diet, cystine deficiency, folate deficiency) or perhaps even the acute vascular events themselves, whereby the tissue damage temporarily increases total homocysteine levels. The results of ongoing clinical trials in stroke patients to determine the impact of multivitamin therapy on recurrent stroke and other serious vascular events are awaited, Curl OpinNeurol 14:95-102. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 14:58:17