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Titolo:
The ischaemic penumbra
Autore:
Touzani, O; Roussel, S; MacKenzie, ET;
Indirizzi:
Univ Caen, CNRS, UMR 6551, Cyceron, France Univ Caen Cyceron FranceUniv Caen, CNRS, UMR 6551, Cyceron, France
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 83 - 88
SICI:
1350-7540(200102)14:1<83:TIP>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MIDDLE CEREBRAL-ARTERY; ACUTE ISCHEMIC STROKE; APPARENT DIFFUSION-COEFFICIENT; NITRIC-OXIDE SYNTHASE; FOCAL BRAIN ISCHEMIA; BLOOD-FLOW; WEIGHTED MRI; F-18 FLUOROMISONIDAZOLE; NEUROPROTECTIVE DRUGS; ANESTHETIZED BABOONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Touzani, O BP 5229, F-14074 Caen, France BP 5229 Caen France F-14074BP 5229, F-14074 Caen, France
Citazione:
O. Touzani et al., "The ischaemic penumbra", CURR OP NEU, 14(1), 2001, pp. 83-88

Abstract

The concept of an ischaemic penumbra, surrounding a focal cerebral lesion,is now widely accepted, although no universal definition of the 'penumbra'exists. In the present review, we consider the penumbra as that volume of brain tissue at the periphery of a focal, irreversibly damaged area that isthreatened by recruitment into necrosis. Implicit to such a definition areseveral secondary concepts. First, the penumbra is both spatial, in that it surrounds the densely ischaemic core, but it is also temporal, in that its evolution toward infarction is a relatively progressive phenomenon. The pertinent literature is summarized. Second, penumbral tissue is potentially salvageable; the most recent animal studies are reviewed. Third, because electrically silent and pathologically damaged tissues have identical functional characteristics, it is evident that most clinical rating scales, be they neurological, behavioural, or psychological, are poorly adapted to address the problem of the penumbra. Finally, the penumbral tissue is remarkably and intensively 'active': multiple processes of cell death and repair occurand involve molecular mechanisms, electrophysiology and the vasculature, Curr Opin Neurol 14:83-88. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:14:17