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Titolo:
Imaging in cerebrovascular disease
Autore:
Heiss, WD; Forsting, M; Diener, HC;
Indirizzi:
Univ Essen, Dept Neurol, D-45122 Essen, Germany Univ Essen Essen GermanyD-45122 en, Dept Neurol, D-45122 Essen, Germany Univ Essen, Dept Neuroradiol, D-45122 Essen, Germany Univ Essen Essen Germany D-45122 ept Neuroradiol, D-45122 Essen, Germany Univ Cologne, Dept Neurol, Cologne, Germany Univ Cologne Cologne Germany niv Cologne, Dept Neurol, Cologne, Germany Max Planck Inst Neurol Res, Cologne, Germany Max Planck Inst Neurol Res Cologne Germany Neurol Res, Cologne, Germany
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 67 - 75
SICI:
1350-7540(200102)14:1<67:IICD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE ISCHEMIC STROKE; POSITRON-EMISSION-TOMOGRAPHY; CEREBRAL BLOOD-FLOW; PERFUSION-WEIGHTED MRI; TIME-OF-FLIGHT; PLASMINOGEN ACTIVATOR THROMBOLYSIS; APPARENT DIFFUSION-COEFFICIENT; COMPUTED-TOMOGRAPHY; HYPERACUTE STROKE; EARLY REPERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
75
Recensione:
Indirizzi per estratti:
Indirizzo: Diener, HC Univ Essen, Dept Neurol, Hufelandstr 55, D-45122 Essen, GermanyUniv Essen Hufelandstr 55 Essen Germany D-45122 Essen, Germany
Citazione:
W.D. Heiss et al., "Imaging in cerebrovascular disease", CURR OP NEU, 14(1), 2001, pp. 67-75

Abstract

Various functional imaging modalities can be applied in acute ischaemic stroke to identify functionally impaired, but morphologically preserved tissue (i.e. the penumbra), and to distinguish it from irreversibly damaged tissue. Flow thresholds for irreversible tissue destruction resulting in functional impairment, as determined by positron emission tomography, perfusion and diffusion-weighted magnetic resonance imaging, single-photon computed tomography and xenon computed tomography, were comparable and ranged between 5 and 12 ml/100 g per min for the lower and 14 and 22 ml/100 g per min for the upper limit of penumbra, These imaging modalities help to select patients for thrombolytic therapy and provide evidence for the effect of this treatment on critically perfused tissue, They can also serve as surrogate markers in the evaluation of therapeutic efficacy, Further progress in interventional neuroradiology has been achieved with intraarterial thrombolysis, which has become a treatment option beyond the 3-h therapeutic window in acute ischaemic stroke. Angioplasty and stenting of stenosis of arteries that supply the brain with blood have reached a point in their development at which a randomized trial to compare these treatments with vascular surgery is warranted, Curr Opin Neurol 14:67-75. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:37:29