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Titolo:
The endocrine system, vertigo and balance
Autore:
Seemungal, BM; Gresty, MA; Bronstein, AM;
Indirizzi:
Natl Hosp Neurol & Neurosurg, MRC, Human Movement & Balance Unit, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg London England WC1N 3BG n WC1N 3BG, England
Titolo Testata:
CURRENT OPINION IN NEUROLOGY
fascicolo: 1, volume: 14, anno: 2001,
pagine: 27 - 34
SICI:
1350-7540(200102)14:1<27:TESVAB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
VESTIBULAR NUCLEUS NEURONS; RAT-BRAIN; GLUCOCORTICOID RECEPTOR; DARK CELLS; INNER-EAR; UNILATERAL LABYRINTHECTOMY; ENDOLYMPHATIC SAC; MENIERES-DISEASE; EPISODIC ATAXIA; K+ SECRETION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Seemungal, BM Natl Hosp Neurol & Neurosurg, MRC, Human Movement & Balance Unit, Queen Sq, London WC1N 3BG, England Natl Hosp Neurol & Neurosurg QueenSq London England WC1N 3BG
Citazione:
B.M. Seemungal et al., "The endocrine system, vertigo and balance", CURR OP NEU, 14(1), 2001, pp. 27-34

Abstract

Steroid, amine and peptide hormones affect the peripheral vestibular system. Vasopressin hypersensitivity of the endolymphatic sac may be implicated in the pathogenesis of Meniere's disease. Specific vasopressin antagonists will help define the role of vasopressin in Meniere's disease. The modulation of central vestibular pathways by neuroactive steroids may involve effects on gamma -aminobutyric acid-ergic and glutaminergic pathways, The vestibular nuclei also express enzymes that are important in the synthesis of steroids and the modulation of their activity. Steroids mediate both facilitatory and deleterious effects of stress on vestibular compensation. The quality and quantity of stressor that determines the pattern of hormonal output,may be important. Clinical observation suggests that episodic ataxia type 2, a P/Q calcium channelopathy, may be phenotypically modulated by endocrine fluctuations. Steroid hormones may affect the episodic ataxia type 2 phenotype by modulation of voltage-gated calcium channel activity via second messenger systems and ion channel subunit expression. Despite evidence to support the link, the role of the endocrine system in vestibular function and disease is as yet virtually unexplored. Curr Opin Neurol 14:27-34. (C) 2001Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 06:23:09