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Titolo:
Role of iron in estrogen-induced cancer
Autore:
Liehr, JG; Jones, JS;
Indirizzi:
Stehlin Fdn Canc Res, Houston, TX 77003 USA Stehlin Fdn Canc Res Houston TX USA 77003 Canc Res, Houston, TX 77003 USA Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA Univ Texas Galveston TX USA 77555 acol & Toxicol, Galveston, TX 77555 USA
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 7, volume: 8, anno: 2001,
pagine: 839 - 849
SICI:
0929-8673(200106)8:7<839:ROIIEC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR CELL-GROWTH; CHEMICALLY DEFINED CULTURE; SINGLE-STRAND BREAKS; MALE SYRIAN-HAMSTERS; FREE-RADICAL DAMAGE; DNA-DAMAGE; MAMMARY CARCINOGENESIS; METABOLIC-ACTIVATION; CATECHOL ESTROGENS; DIETARY IRON;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
127
Recensione:
Indirizzi per estratti:
Indirizzo: Liehr, JG Stehlin Fdn Canc Res, 1918 Chenevert, Houston, TX 77003 USA Stehlin Fdn Canc Res 1918 Chenevert Houston TX USA 77003 003 USA
Citazione:
J.G. Liehr e J.S. Jones, "Role of iron in estrogen-induced cancer", CURR MED CH, 8(7), 2001, pp. 839-849

Abstract

Redox cycling of catecholestrogen metabolites between quinone and catecholforms is a mechanism of generating potentially mutagenic oxygen radicals in estrogen-induced carcinogenesis. Consistent with this concept, multiple forms of oxygen radical-generated DNA damage are induced by estrogen in cell-free systems, in cells in culture and in rodents prone to estrogen-inducedcancer. Metal ions, specifically iron, are necessary for the production ofhydroxy radicals. Iron has not received much attention in discussions of estrogen-induced carcinogenesis and human hormone-associated cancer, and is the focus of this review. An elevated dietary iron intake enhances the incidence of carcinogen-induced mammary cancer in rats and estrogen-induced kidney tumors in Syrian hamsters. Estrogen administration increases iron accumulation in hamsters and facilitates iron uptake by cells in culture. In humans, elevated body iron storage has been shown to increase the risk of several cancers including breast cancer. A role of iron in hormone-associated cancer in humans offers attractive routes for cancer prevention by regulating metal ion metabolism and interfering with iron accumulation in tissues.

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Documento generato il 04/04/20 alle ore 21:16:45