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Titolo:
Parkinson's disease - Redox mechanisms
Autore:
Adams, JD; Chang, ML; Klaidman, L;
Indirizzi:
Univ So Calif, Sch Pharm, Los Angeles, CA 90089 USA Univ So Calif Los Angeles CA USA 90089 h Pharm, Los Angeles, CA 90089 USA
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 7, volume: 8, anno: 2001,
pagine: 809 - 814
SICI:
0929-8673(200106)8:7<809:PD-RM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN RADICAL FORMATION; TYROSINE-HYDROXYLASE; ALDEHYDE DEHYDROGENASE; HYDRIDE TRANSFER; MPP+; DOPAMINE; MPTP; INHIBITION; QUINONES; TOXICITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Adams, JD Univ So Calif, Sch Pharm, 1985 Zonal Ave,PSC 508, Los Angeles, CA 90089 USA Univ So Calif 1985 Zonal Ave,PSC 508 Los Angeles CA USA 90089 SA
Citazione:
J.D. Adams et al., "Parkinson's disease - Redox mechanisms", CURR MED CH, 8(7), 2001, pp. 809-814

Abstract

Parkinson's disease occurs in 1% of people over the age of 65 when about 60% of the dopaminergic neurons in the substantia nigra of the midbrain are lost. Dopaminergic neurons appear to die by a process of apoptosis that is induced by oxidative stress. Oxygen radicals abstract hydrogen from DNA forming DNA radicals that lead to DNA fragmentation, activation of DNA protective mechanisms, NAD depletion and apoptosis. Oxygen radicals can be formed in dopaminergic neurons by redox cycling of MPP+, the active metabolite of MPTP. This redox cycling mechanism involves the reduction of MPP+ by a number of enzymes, especially flavin containing enzymes, some of which are found in mitochondria. Tyrosine hydroxylase is present in all dopaminergic neurons and is responsible for the synthesis of dopamine. However, tyrosine hydroxylase can form oxygen radicals in a redox mechanism involving its cofactor, tetrahydrobiopterin. Dopamine may be oxidized by monoamine oxidase to form oxygen radicals and 3,4-dihydroxyphenylacetaldehyde. This aldehyde may be oxidized by aldehyde dehydrogenase with the formation of oxygen radicalsand 3,4-dihydroxyphenylacetic acid. The redox mechanisms of oxygen radicalformation by MPTP, tyrosine hydroxylase, monoamine oxidase and aldehyde dehydrogenase will be discussed. Possible clinical applications of these mechanisms will be briefly presented.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:47:31