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Titolo:
Chemistry and biochemistry of oxidative stress in neurodegenerative disease
Autore:
Sayre, LM; Smith, MA; Perry, G;
Indirizzi:
Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA Case WesternReserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 7, volume: 8, anno: 2001,
pagine: 721 - 738
SICI:
0929-8673(200106)8:7<721:CABOOS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; PAIRED HELICAL FILAMENTS; METAL-CATALYZED OXIDATION; LEWY-BODY-DISEASE; N-ALPHA-HIPPURYLLYSINE; GLYCATION END-PRODUCTS; CU,ZN-SUPEROXIDE DISMUTASE MUTANT; 4-HYDROXYNONENAL PROTEIN ADDUCTS; PARKINSONIAN SUBSTANTIA-NIGRA; AMYLOID PRECURSOR PROTEIN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
232
Recensione:
Indirizzi per estratti:
Indirizzo: Sayre, LM Case Western Reserve Univ, Dept Chem, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 , OH 44106 USA
Citazione:
L.M. Sayre et al., "Chemistry and biochemistry of oxidative stress in neurodegenerative disease", CURR MED CH, 8(7), 2001, pp. 721-738

Abstract

The age-related neurodegenerative diseases exemplified by Alzheimer's disease (AD), Lewy body diseases such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease are characterized by the deposition of abnormal forms of specific proteins in the brain. Although several Factors appear to underlie the pathological depositions, the cause ofneuronal death in each disease appears to be multifactorial. In this regard, evidence in each case for a role of oxidative stress is provided by the finding that the pathological deposits are immunoreactive to antibodies recognizing protein side-chains modified either directly by reactive oxygen ornitrogen species, or by products of lipid peroxidation or glycoxidation. Although the source(s) of increased oxidative damage are not entirely clear,the findings of increased localization of redox-active transition metals in the brain regions most affected is consistent with their contribution to oxidative stress. It is tempting to speculate that free radical oxygen chemistry plays a pathogenetic role in all these neurodegenerative conditions, though it is as yet undetermined what types of oxidative damage occur earlyin pathogenesis, and what types are secondary manifestations of dying neurons. Delineation of the profile of oxidative damage in each disease will provide clues to how the specific neuronal populations are differentially affected by the individual disease conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:57:31