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Titolo:
New therapeutic modalities in the treatment of graft-versus-host disease
Autore:
Basara, N; Kiehl, MG; Fauser, AA;
Indirizzi:
Clin Bone Marrow Transplantat & Haematol Oncol, D-55743 Idar, Oberstein, Germany Clin Bone Marrow Transplantat & Haematol Oncol Idar Oberstein Germany D-55743
Titolo Testata:
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
fascicolo: 2, volume: 38, anno: 2001,
pagine: 129 - 138
SICI:
1040-8428(200105)38:2<129:NTMITT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; MYCOPHENOLATE-MOFETIL MMF; STEM-CELL TRANSPLANTATION; MATCHED UNRELATED DONORS; RANDOMIZED TRIAL; ACUTE GVHD; HEMATOLOGIC MALIGNANCIES; SELECTIVE DEPLETION; SECONDARY-TREATMENT; THYMOCYTE GLOBULIN;
Keywords:
mycophenolate mofetil; GvHD; haemopoietic stem cell transplantation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Basara, N Clin Bone Marrow Transplantat & Haematol Oncol, Dr Ottmar KohlerStr 2, D-55743 Idar, Oberstein, Germany Clin Bone Marrow Transplantat & Haematol Oncol Dr Ottmar Kohler Str 2 Idar Oberstein Germany D-55743
Citazione:
N. Basara et al., "New therapeutic modalities in the treatment of graft-versus-host disease", CR R ONC H, 38(2), 2001, pp. 129-138

Abstract

Acute and chronic GVHD are still a major concern in allogeneic hematopoietic stem cell transplantation, still contributing substantially to morbidityand mortality in this therapeutic procedure. Over the past decade, many advances have been made with regard to the prevention and treatment of GvHD using various drugs such as cyclosporine A, FK506, mycophenolate mofetil and/or monoclonal IL-2 receptor antagonists. Despite these measurements with regard to the prevention of acute GVHD, it is very difficult to treat these clinical conditions successfully. However, if patients do not experience any GvHD often the desired effect of graft versus leukemia (GvL) remains absent increasing the probability of a relapse, in particular, in patients transplanted, which are considered at higher risk for relapse. At the present time, new strategies in the prevention of acute GvHD are in progress in particular the use of genetic manipulated donor T cells expressing suicide genes. Further clinical and laboratory studies are required in order to improvethe prevention and. in particular, the therapy of established GvHD. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:49:00