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Titolo:
Molecular markers predictive of response to chemotherapy in gastrointestinal tumors
Autore:
Catalano, V; Baldelli, AM; Giordani, P; Cascinu, S;
Indirizzi:
Azienda Osped S Salvatore, Dept Med Oncol, I-61100 Pesaro, Italy Azienda Osped S Salvatore Pesaro Italy I-61100 ol, I-61100 Pesaro, Italy Azienda Osped, Dept Med Oncol, I-43100 Parma, Italy Azienda Osped Parma Italy I-43100 , Dept Med Oncol, I-43100 Parma, Italy
Titolo Testata:
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
fascicolo: 2, volume: 38, anno: 2001,
pagine: 93 - 104
SICI:
1040-8428(200105)38:2<93:MMPORT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDYLATE SYNTHASE EXPRESSION; ENDOTHELIAL-CELL GROWTH; P53 PROTEIN OVEREXPRESSION; ADVANCED COLORECTAL-CANCER; ADVANCED GASTRIC-CANCER; 5-FLUOROURACIL-BASED SYSTEMIC CHEMOTHERAPY; FACTOR THYMIDINE PHOSPHORYLASE; COLON-CARCINOMA CELLS; GENE-SPECIFIC REPAIR; MESSENGER-RNA LEVELS;
Keywords:
biological markers; molecular markers; chemotherapy; gastrointestinal tumors; chemosensitivity; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
93
Recensione:
Indirizzi per estratti:
Indirizzo: Catalano, V Azienda Osped S Salvatore, Dept Med Oncol, I-61100 Pesaro, Italy Azienda Osped S Salvatore Pesaro Italy I-61100 Pesaro, Italy
Citazione:
V. Catalano et al., "Molecular markers predictive of response to chemotherapy in gastrointestinal tumors", CR R ONC H, 38(2), 2001, pp. 93-104

Abstract

Gastrointestinal cancers account for a large amount of human tumors. Surgery is the standard treatment for localized gastrointestinal cancer, but in a large number of patients, tumors are unresectable at time of diagnosis and even when resectable, survival is often poor. Curl ent attempts to improve these results include the use of chemotherapy in the adjuvant setting, inthe advanced disease, or as neoadjuvant treatment. However, less than halfthe patients respond to chemotherapeutic treatments, mostly reporting important side-effects. The identification of molecular markers, such as p53, thymidylate synthase, K-ras, and others, may provide an important tool for medical oncologists in defining subsets of patients with gastrointestinal cancers more suitable to benefit from chemotherapy or from experimental therapies. The relationship between the clinical outcome to anticancer drugs andmolecular markers in gastrointestinal tumors has been reviewed. Available data are promising, but most of them arise from retrospective and small studies. Well designed, prospective trials are warranted to change the target approach from a general to an individual treatment strategy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:29:38