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Titolo:
Mamu-DQA1 allele and genotype frequencies in a randomly sampled breeding colony of rhesus macaques (Macaca mulatta)
Autore:
Rolfs, BK; Lorenz, JG; Wu, CC; Lerche, NW; Smith, DG;
Indirizzi:
Univ Calif Davis, Sch Vet Med, Dept Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 et Med, Dept Med, Davis, CA 95616 USA Univ Calif Davis, Sch Vet Med, Dept Epidemiol, Davis, CA USA Univ Calif Davis Davis CA USA Sch Vet Med, Dept Epidemiol, Davis, CA USA Coriell Inst Med Res, Camden, NJ USA Coriell Inst Med Res Camden NJ USACoriell Inst Med Res, Camden, NJ USA Purdue Univ, Dept Vet Pathol, W Lafayette, IN 47907 USA Purdue Univ W Lafayette IN USA 47907 et Pathol, W Lafayette, IN 47907 USA Calif Reg Primate Res Ctr, Davis, CA USA Calif Reg Primate Res Ctr Davis CA USA eg Primate Res Ctr, Davis, CA USA Univ Calif Davis, Dept Anthropol, Davis, CA USA Univ Calif Davis Davis CAUSA Calif Davis, Dept Anthropol, Davis, CA USA
Titolo Testata:
COMPARATIVE MEDICINE
fascicolo: 2, volume: 51, anno: 2001,
pagine: 156 - 162
SICI:
1532-0820(200104)51:2<156:MAAGFI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; SIMIAN IMMUNODEFICIENCY VIRUS; DQ-ALPHA ALLELE; HLA-DQ; HELICOBACTER-PYLORI; DISEASE PROGRESSION; SEQUENCE-ANALYSIS; CELIAC-DISEASE; INFECTION; PRIMATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Rolfs, BK Univ Calif Davis, Sch Vet Med, Dept Med, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 pt Med, Davis, CA 95616 USA
Citazione:
B.K. Rolfs et al., "Mamu-DQA1 allele and genotype frequencies in a randomly sampled breeding colony of rhesus macaques (Macaca mulatta)", COMPAR MED, 51(2), 2001, pp. 156-162

Abstract

We studied the allelic and genotypic distribution of the major histocompatibility class-II locus DQA1 observed in a random sample of Indian rhesus macaques (Macaca mulatta) from a major breeding facility in the United States. The DNA was isolated from whole blood samples collected between 1991 and 1994 from 65 Indian rhesus monkeys. Polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP), which involves use of specific amplification of DQA1 exon 2 and subsequent restriction digestion of the 242-base pair fragment, was used to genotype the animals for the 20 known macaque (Mamu)-DQA1 alleles, Frequencies for four alleles (DQA1*240x, *2502, *2503 and *0102) differed significantly from those reported in a smaller sample of rhesus macaques from the German Primate Center. The modest genetic survey of Mamu-DQA1 genotypes presented here will be particularly useful in designing epidemiologic studies that investigate associations between immunogenetic background and disease susceptibility in macaque models of human disease.

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Documento generato il 29/03/20 alle ore 18:23:06