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Titolo:
Coexistent Marfan's syndrome and ankylosing spondylitis: A case report
Autore:
Fietta, P; Manganelli, P;
Indirizzi:
Azienda Osped Parma, Div Med & Reumatol 2, I-43100 Parma, Italy Azienda Osped Parma Parma Italy I-43100 Reumatol 2, I-43100 Parma, Italy
Titolo Testata:
CLINICAL RHEUMATOLOGY
fascicolo: 2, volume: 20, anno: 2001,
pagine: 140 - 142
SICI:
0770-3198(2001)20:2<140:CMSAAS>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MISSENSE MUTATION; FIBRILLIN GENE;
Keywords:
ankylosing spondylitis; echo-cardiography; HLA-B27; Marfan's syndrome;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Manganelli, P Azienda Osped Parma, Div Med & Reumatol 2, Via Gramsci 14, I-43100 Parma, Italy Azienda Osped Parma Via Gramsci 14 Parma Italy I-43100taly
Citazione:
P. Fietta e P. Manganelli, "Coexistent Marfan's syndrome and ankylosing spondylitis: A case report", CLIN RHEUMA, 20(2), 2001, pp. 140-142

Abstract

We report on a 46-year-old man with a 4-year history of predominantly nocturnal pain at the thoracic and lumbar spine as well as accompanying morningstiffness and episodes of alternating buttock pain. At physical examination the patient presented with the typical traits for Marfan's syndrome (MFS), along with limitation of both chest expansion and movement in all planes of the lumbar spine. Pelvic and lumbar spine radiographs showed findings consistent with ankylosing spondylitis (AS). Laboratory tests were consistentwith an inflammatory state and HLA typing was positive for the B27 antigen. Transthoracic echocardiography showed prolapse of the posterior mitral leaflet and mild aortic insufficiency. We diagnosed co-existent MFS and AS. The association of these two pathologies is particularly interesting, owing to the co-existence of hypermobility of peripheral joints due to MFS ligamentous hyperlaxity, and the reduction of both axial skeleton motility and chest expansion related to AS. As both of these diseases may damage the cardiovascular system over time, follow-up with echocardiography monitoring is indispensable

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 14:43:05