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Titolo:
Reference values for plasma dipeptidyl-peptidase IV activity and iheir association with other laboratory parameters
Autore:
Durinx, C; Neels, H; Van der Auwera, JC; Naelaerts, K; Scharpe, S; De Meester, I;
Indirizzi:
Univ Instelling Antwerp, Biochim Clin Lab, B-2610 Wilrijk, Belgium Univ Instelling Antwerp Wilrijk Belgium B-2610 , B-2610 Wilrijk, Belgium OCMW Hosp, Lab Clin Biol, Antwerp, Belgium OCMW Hosp Antwerp BelgiumOCMW Hosp, Lab Clin Biol, Antwerp, Belgium
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 155 - 159
SICI:
1434-6621(200102)39:2<155:RVFPDI>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; AMINO-TERMINAL TRUNCATION; ORAL-CANCER PATIENTS; RHEUMATOID-ARTHRITIS; EC-3.4.14.5 ACTIVITY; AMINOPEPTIDASE-IV; SERINE-PROTEASE; HUMAN-SERUM; IN-VIVO; CD26;
Keywords:
dipeptidyl-peptidase IV; CD26; reference values; multiple regression analysis; gender; hormone replacement therapy; contraception;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: De Meester, I Univ Instelling Antwerp, Biochim Clin Lab, Univ Pl 1, B-2610Wilrijk, Belgium Univ Instelling Antwerp Univ Pl 1 Wilrijk Belgium B-2610um
Citazione:
C. Durinx et al., "Reference values for plasma dipeptidyl-peptidase IV activity and iheir association with other laboratory parameters", CLIN CH L M, 39(2), 2001, pp. 155-159

Abstract

In blood, the exopeptidase dipeptidyl-peptidase IV (DPPIV; EC 3.4.14.5) ispredominantly present in a soluble form in plasma/serum and as an activation antigen on the membrane of lymphocytes (CD26). It modifies some important biologically active peptides (neuropeptides, chemokines), and a regulatory role for DPPlV/CD26 in immune and endocrine processes has been demonstrated. The aim of this study was to determine reference values for plasma/serum DPPIV activity and to study the association of this activity with a series of biochemical and hematological parameters and baseline characteristics such as age, gender, blood pressure and body mass index. We studied 481 healthy subjects aged between 19 and 61 years. The group consisted of 213 men and268 women equally divided between the different categories of age. Among the women, 127 were taking hormone therapy (contraception/hormone replacement) and 141 were not. A multiple regression model shows that DPPIV activity decreases significantly with age. The activity in women is slightly lower than in men. We observed an important association with liver, muscle and lipid metabolism-related parameters. In this model, no significant contribution of body mass index, blood pressure or hormone therapy could be stated.

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Documento generato il 19/01/20 alle ore 15:13:07