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Titolo:
Candidate gene polymorphisms in cardiovascular disease: A comparative study of frequencies between a French and an Italian population
Autore:
Pallaud, C; Stranieri, C; Sass, C; Siest, G; Pignatti, F; Visvikis, S;
Indirizzi:
Ctr Med Prevent, INSERM, U525, F-54501 Vandoeuvre Nancy, France Ctr Med Prevent Vandoeuvre Nancy France F-54501 Vandoeuvre Nancy, France Univ Verona, Dept Mother Child Biol Genet, I-37100 Verona, Italy Univ Verona Verona Italy I-37100 Child Biol Genet, I-37100 Verona, Italy
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 146 - 154
SICI:
1434-6621(200102)39:2<146:CGPICD>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; FAMILIAL COMBINED HYPERLIPIDEMIA; MYOCARDIAL-INFARCTION SURVIVORS; CONVERTING-ENZYME GENE; THERMOLABILE METHYLENETETRAHYDROFOLATE REDUCTASE; DIFFERENT EUROPEAN POPULATIONS; PLATELET GLYCOPROTEIN IIIA; RENIN-ANGIOTENSIN SYSTEM; HIGH-DENSITY-LIPOPROTEIN; HUMAN PARAOXONASE GENE;
Keywords:
cardiovascular disease; gene polymorphism; frequencies; comparative study;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Visvikis, S Ctr Med Prevent, INSERM, U525, 2 Ave Doyen Jacques Parisot, F-54501 Vandoeuvre Nancy, France Ctr Med Prevent 2 Ave Doyen Jacques Parisot Vandoeuvre Nancy France F-54501
Citazione:
C. Pallaud et al., "Candidate gene polymorphisms in cardiovascular disease: A comparative study of frequencies between a French and an Italian population", CLIN CH L M, 39(2), 2001, pp. 146-154

Abstract

A multilocus assay was used to genotype up to 27 variable sites in 15 genes in French and Italian, presumed to be healthy populations (n=1480, n=162,respectively). These genes are involved in lipid metabolism (APOE, APOB, APOC3, CETP, LPL, PON), homocysteine metabolism (CBS, MTHFR), blood viscosity (Fibrinogen, FV), platelet aggregation (GpIIIa), leukocyte adhesion (SELE), and renin-angiotensin system (AT1R, ACE, AGT). Allele frequencies for all the markers were compared between the two populations. Five allele frequencies differed between the two European countries: APOB 71Ile (p less than or equal to 0.001), SELE 98T (p <0.001), SELE 128Arg (p less than or equal to0.01), APOE epsilon4 (p less than or equal to 0.01) and MTHFR 677T tp I 0.01), suggesting the existence of a north-south gradient in European allelefrequencies. The other allele frequencies : APOC3 -482T, -455C, 1100T, 3175G, 3206G; LPL -93G, 9Asn, 291Ser; CETP 405Val; PON 192Arg; ACE Del; AGT 235Thr; AT1R 1166C; CBS 278Thr, GpIIIa P1(A2); Fibrinogen -455A, N 506Gln andSELE 554Phe, were similar between the two populations. They were also similar to those observed in other European countries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:10:56