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Titolo:
Diabetic cataract and the total antioxidant status in aqueous humor
Autore:
Aksoy, H; Keles, S; Kocer, I; Akcay, F;
Indirizzi:
Ataturk Univ, Sch Med, Dept Biochem, TR-25240 Erzurum, Turkey Ataturk Univ Erzurum Turkey TR-25240 t Biochem, TR-25240 Erzurum, Turkey Ataturk Univ, Sch Med, Dept Ophthalmol, Erzurum, Turkey Ataturk Univ Erzurum Turkey , Sch Med, Dept Ophthalmol, Erzurum, Turkey
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 143 - 145
SICI:
1434-6621(200102)39:2<143:DCATTA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAPACITY; MELLITUS; FLUIDS; SERUM;
Keywords:
diabetes, cataract; antioxidant status; aqueous humor; uric acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Aksoy, H Ataturk Univ, Sch Med, Dept Biochem, TR-25240 Erzurum, Turkey Ataturk Univ Erzurum Turkey TR-25240 , TR-25240 Erzurum, Turkey
Citazione:
H. Aksoy et al., "Diabetic cataract and the total antioxidant status in aqueous humor", CLIN CH L M, 39(2), 2001, pp. 143-145

Abstract

Some mechanisms have been proposed for cataract formation in diabetes mellitus such as excessive tissue sorbitol concentrations, abnormal glycosylation of lens proteins and increased free radical production in the intraocular region. We measured total antioxidant status and uric acid levels in aqueous humor from diabetic (n=20) and non-diabetic subjects (n=16) with cataracts. The patients with diabetes and cataract had significantly lower aqueous humor total antioxidant status than those with senile cataract (p = 0.001). Serum and aqueous humor uric acid levels were significantly lower in thediabetic cataract group compared to the senile cataract group. In the diabetic cataract group, the aqueous humor antioxidant status correlated positively with the aqueous humor uric acid levels (p < 0.05). The results of this study suggest that reduced aqueous humor antioxidant status might be associated with reduced aqueous humor uric acid in patients with diabetic cataract. This decrease in aqueous humor uric acid levels might lead to the acceleration of cataract formation.

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Documento generato il 10/04/20 alle ore 16:01:02