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Titolo:
Serum amyloid A protein (SAA) in colorectal carcinoma
Autore:
Glojnaric, I; Casl, MT; Simic, D; Lukac, J;
Indirizzi:
PLIVA DD, Res & Dev, Pharmacol & Toxicol, Zagreb 10000, Croatia PLIVA DD Zagreb Croatia 10000 Pharmacol & Toxicol, Zagreb 10000, Croatia Tinolab Co Zagreb, R&D Lab, Zagreb, Croatia Tinolab Co Zagreb Zagreb Croatia ab Co Zagreb, R&D Lab, Zagreb, Croatia Inst Med Res & Occupat Hlth, Zagreb 41000, Croatia Inst Med Res & Occupat Hlth Zagreb Croatia 41000 , Zagreb 41000, Croatia Clin Hosp Sestre Milosrdnice, Nucl Med & Oncol Clin, Zagreb, Croatia Clin Hosp Sestre Milosrdnice Zagreb Croatia Oncol Clin, Zagreb, Croatia
Titolo Testata:
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
fascicolo: 2, volume: 39, anno: 2001,
pagine: 129 - 133
SICI:
1434-6621(200102)39:2<129:SAAP(I>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE-PHASE PROTEINS; C-REACTIVE PROTEIN; ACUTE MYOCARDIAL-INFARCTION; A PROTEIN; DIAGNOSTIC CAPACITY; CLINICAL-PRACTICE; CANCER; DISEASE; PREDICTION; REACTANT;
Keywords:
serum amyloid A protein; acute phase reaction; colorectal carcinoma; tumour marker; ELISA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Glojnaric, I PLIVA DD, Res & Dev, Pharmacol & Toxicol, Prilaz Baruna Filipovica 25, Zagreb 10000, Croatia PLIVA DD Prilaz Baruna Filipovica 25 Zagreb Croatia 10000 ia
Citazione:
I. Glojnaric et al., "Serum amyloid A protein (SAA) in colorectal carcinoma", CLIN CH L M, 39(2), 2001, pp. 129-133

Abstract

The changes in serum levels of serum amyloid A protein were studied in 67 patients suffering from colorectal carcinoma and compared to three other major acute phase proteins: C-reactive protein, alpha (1)-antichymotrypsin and alpha (1)-acid glycoprotein. Although the presence of colorectal carcinoma caused an increase in serum levels of all the acute phase reactants studied, serum amyloid A protein showed the most powerful reaction in pre-operative disease stage, with the mean value of 330 mg/l (range 7-2506 mg/l) as compared to the normal values of <1.2 mg/l obtained in 30 healthy adults. The mean serum amyloid A protein concentration increased to 487 mg/l after surgery, declining during the post-operative clinical course until the sixth chemotherapy cycle (from 167 mg/l to 64 mg/l), but never returned to the normal range. In the later chemotherapy cycles, mean serum amyloid A protein increased to 163 mg/l, probably as a result of the disease relapse. According to the statistical relations among exact confidence intervals for proportions, serum amyloid A protein showed the best specificity for colorectal carcinoma of all the acute phase proteins studied (83-100%) and also a sensitivity of 100%. We concluded that serum amyloid A protein seems to be a reliable parameter, which could be recommended for clinical routine as a non-specific tumour marker for colorectal carcinoma.

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Documento generato il 26/01/20 alle ore 16:12:20