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Titolo:
Inhibition of phosphatidylinositol-3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-alpha cytotoxicity
Autore:
Zhang, L; Himi, T; Morita, I; Murota, S;
Indirizzi:
Tokyo Med & Dent Univ, Grad Sch, Dept Cellular Physiol Chem, Bunkyo Ku, Tokyo 1138549, Japan Tokyo Med & Dent Univ Tokyo Japan 1138549 unkyo Ku, Tokyo 1138549, Japan
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 5, volume: 8, anno: 2001,
pagine: 528 - 536
SICI:
1350-9047(200105)8:5<528:IOPKOM>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; CYTOCHROME-C RELEASE; RIBOSOMAL S6 KINASE; INDUCED APOPTOSIS; IN-VITRO; DEATH; SURVIVAL; AKT; PATHWAY;
Keywords:
apoptosis; tumor necrosis factor-alpha; MAP kinase; Pl3-kinase; Akt;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Morita, I Tokyo Med & Dent Univ, Grad Sch, Dept Cellular Physiol Chem, Bunkyo Ku, 1-5-45 Yushima, Tokyo 1138549, Japan Tokyo Med & Dent Univ 1-5-45 Yushima Tokyo Japan 1138549 Japan
Citazione:
L. Zhang et al., "Inhibition of phosphatidylinositol-3 kinase/Akt or mitogen-activated protein kinase signaling sensitizes endothelial cells to TNF-alpha cytotoxicity", CELL DEAT D, 8(5), 2001, pp. 528-536

Abstract

Bovine carotid artery endothelial (BAE) cells are resistant to tumor necrosis factor-alpha (TNF), like most other cells. We examined if mitogen-activated protein (MAP) kinase and phosphatidylinositol-3(Pl3) kinase/Akt pathways are involved in this effect. In BAE cells, TNF activates MAP kinase in aMAP kinase kinase 1 (MEK1) manner and Akt in Pl3-kinase-dependent manner, Pretreatment with either the MEK1 Inhibitor U0126 or Pl3 kinase inhibitor LY294002 sensitized BAE cells to TNF-induced apoptosis. Neither U0126 nor LY294002 pretreatment affected TNF-induced activation of NF-kappaB, suggesting that the MAP kinase or Pl3-kinase/Akt-mediated anti-apoptotic effect induced by TNF was not relevant to NF-kappaB activation, Both MAP kinase and P13 kinase/Akt-mediated signaling could prevent cytochrome c release and mitochondrial transmembrane potential (Delta Psi) decrease. Pl3-kinase/Akt signaling attenuated caspase-8 activity, whereas MAP kinase signaling impaired caspase-9 activity. These results suggest that TNF-induced MAP kinase and Pl3-kinase/Akt signaling play important roles In protecting BAE cells from TNF cytotoxicity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 03:34:27