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Titolo:
Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells
Autore:
Tentori, L; Portarena, I; Bonmassar, E; Graziani, G;
Indirizzi:
Univ Roma Tor Vergata, Dept Neurosci, Pharmacol & Med Oncol Sect, I-00133 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00133 Oncol Sect, I-00133 Rome, Italy IRCCS, IDI, Rome, Italy IRCCS Rome ItalyIRCCS, IDI, Rome, Italy
Titolo Testata:
CELL DEATH AND DIFFERENTIATION
fascicolo: 5, volume: 8, anno: 2001,
pagine: 457 - 469
SICI:
1350-9047(200105)8:5<457:CEOAWP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHASE-II TRIAL; COLON-CANCER CELLS; HUMAN GLIOMA-CELLS; GENE-TRANSFER; POLY(ADP-RIBOSE) POLYMERASE; LUNG-CANCER; IN-VIVO; MICROSATELLITE INSTABILITY; ANTICANCER DRUG; SUPPRESSOR GENE;
Keywords:
DNA repair; chemotherapy; methylating agents; drug resistance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Graziani, G Univ Roma Tor Vergata, Dept Neurosci, Pharmacol & Med Oncol Sect, Via Tor Vergata 135, I-00133 Rome, Italy Univ Roma Tor Vergata Via Tor Vergata 135 Rome Italy I-00133
Citazione:
L. Tentori et al., "Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells", CELL DEAT D, 8(5), 2001, pp. 457-469

Abstract

Lack of p53 or mismatch repair (MR) function and scarce cell proliferationare commonly associated with tumor cell resistance to antineoplastic agents, Recently, inhibition of poly(ADP-ribose) polymerase(PARP) has been cons ide red as a tool to overcome resistance of MR-deficient tumors to methylating agents. In the present study we demonstrated that infection with p53 expressing adenovirus (Ad-p53), enhances chemosensitivity of MR-deficient tumor cell lines to the methylating agent temozolomide (TZM), either used as single agent or, more efficiently, when combined with PARP inhibitor. Moreover, the association of Ad-p53 with drug treatment induced a more pronouncedgrowth inhibitory effect than that provoked by Ad-p53 infection only. Cells, growth arrested by p53 transduction, and then subsequently exposed to the drugs, were still highly susceptible to cytotoxicity induced by TZM and PARP inhibitor. The results suggested that this drug combination might be effective even in nonproliferating tumor cells, It is conceivable to envisagefuture possible strategies to enhance cytostatic or cytotoxic effects induced by Ad-p53, based on the use of TZM, alone or combined with PARP inhibitor for the therapy of resistant tumors.

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Documento generato il 13/07/20 alle ore 17:47:53