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Titolo:
Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma
Autore:
Ohno, R; Yoshinaga, K; Fujita, T; Hasegawa, K; Iseki, H; Tsunozaki, H; Ichikawa, W; Nihei, Z; Sugihara, K;
Indirizzi:
Tokyo Med & Dent Univ, Dept Surg 2, Bunkyo Ku, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 unkyo Ku, Tokyo 1138519, Japan
Titolo Testata:
CANCER
fascicolo: 10, volume: 91, anno: 2001,
pagine: 1876 - 1881
SICI:
0008-543X(20010515)91:10<1876:DOIPIC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN G/H SYNTHASE-1; HUMAN COLON-CANCER; EXPRESSION; PROTEIN; ASPIRIN; ADENOCARCINOMAS; OVEREXPRESSION; PROLIFERATION; INHIBITION; POLYPOSIS;
Keywords:
gastric carcinoma; cyclooxygenase-2; invasion; reverse transcription-polymerase chain reaction; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ohno, R Tokyo Med & Dent Univ, Dept Surg 2, Bunkyo Ku, Yushima 1-5-45, Tokyo 1138519, Japan Tokyo Med & Dent Univ Yushima 1-5-45 Tokyo Japan 11385199, Japan
Citazione:
R. Ohno et al., "Depth of invasion parallels increased cyclooxygenase-2 levels in patients with gastric carcinoma", CANCER, 91(10), 2001, pp. 1876-1881

Abstract

BACKGROUND. Nonsteroidal anti-inflammatory drugs may reduce the incidence of intestinal carcinoma, presumably through inhibition of cyclooxygenase-2 (COX-2). The authors correlated tumor expression of COX-2 with clinicopathologic features in tissues from patients with gastric carcinoma. METHODS. Thirty-three surgical specimens, including carcinomas and corresponding noncancerous mucosa, were sampled. Reverse transcription-polymerase chain reaction analysis was performed concomitantly for COS-1 and COX-2. A COS-2 index was determined from the band density ratio of COX-2 to constitutively expressed COX-1. Immunohistochemical; staining with COX-2 antibody and routine histologic assessment were performed in the same specimens. RESULTS. The COX-2 index in gastric carcinoma was significantly higher than in normal mucosa (3.4 +/- 0.7 vs. 2.2 +/- 0.7; P < 0.05). COS-2 indices were significantly higher in gastric carcinoma tissues with deep invasion; indices for pT1, pT2, pT3, and pT4 carcinomas were 0.8 <plus/minus> 0.31 2.8+/- 0.5, 4.3 +/- 1.0, and 8.8 +/- 5.5, respectively (P < 0.05). Immunohistochemistry demonstrated COS-2 protein diffusely in the cytoplasm of tumor cells hut not in surrounding stroma or in noncancerous mucosa. CONCLUSIONS, COX-2 mRNA expression in gastric carcinoma tissue is correlated closely with depth of invasion, indicating that COX-2 is involved in thegrowth of gastric carcinoma. <(c)> 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:59:11