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Titolo:
Modulation of AMPA receptors by a novel organic nitrate
Autore:
Toong, S; Xiong, ZG; Zavorin, SI; Bai, DL; Orser, BA; Thatcher, GRJ; Reynolds, JN; MacDonald, JF;
Indirizzi:
Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 ysiol, Toronto, ON M5S 1A8, Canada Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A8, Canada Univ Toronto Toronto ON Canada M5S 1A8 macol, Toronto, ON M5S 1A8, Canada Queens Univ, Dept Chem, Kingston, ON K7L 3N6, Canada Queens Univ KingstonON Canada K7L 3N6 Chem, Kingston, ON K7L 3N6, Canada Queens Univ, Dept Pharmacol & Toxicol, Kingston, ON K7L 3N6, Canada QueensUniv Kingston ON Canada K7L 3N6 icol, Kingston, ON K7L 3N6, Canada
Titolo Testata:
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
fascicolo: 5, volume: 79, anno: 2001,
pagine: 422 - 429
SICI:
0008-4212(200105)79:5<422:MOARBA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL SLICES; D-ASPARTATE RECEPTORS; SYNAPTIC TRANSMISSION; KAINATE RECEPTORS; PYRAMIDAL CELLS; DESENSITIZATION; NEURONS; GLUTAMATE; PATCHES; CYCLOTHIAZIDE;
Keywords:
AMPA receptors; desensitization; organic nitrates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: MacDonald, JF Univ Toronto, Dept Physiol, Med Sci Bldg, Toronto, ON M5S 1A8, Canada Univ Toronto Med Sci Bldg Toronto ON Canada M5S 1A8 , Canada
Citazione:
S. Toong et al., "Modulation of AMPA receptors by a novel organic nitrate", CAN J PHYSL, 79(5), 2001, pp. 422-429

Abstract

Positive modulators of alpha -amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) channels reduce desensitization and alter their gating kinetics. We have discovered a novel compound nitric oxide-mimetic that similarlymodulates the AMPA receptor by reducing desensitization. This, designated GT-005, belongs to the organic nitrate family that includes the nitrovasodilator nitroglycerine. In acutely isolated hippocampal neurons, GT-005 enhanced kainate (100 muM)-evoked currents with an EC50 of 1.7 +/- 0.2 mM and a 176 +/- 10% maximal increase in the steady-state current response. Similar results were found in cultured hippocampal neurons (EC50 of 1.3 +/- 0.2 mM and a maximal 83 +/- 14% increase in the steady-state current response). GT-005 reduced the desensitization of glutamate-evoked currents and slowed the onset of desensitization. This compound also increased the rate of recovery from the desensitized state. With respect to alteration of the excitatory synaptic transmission, GT-005 delayed the decay and increased the frequency of spontaneous miniature excitatory postsynaptic currents (mepsc) recorded in cultured hippocampal neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 18:32:32