Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currentsin substantia gelatinosa neurons of rat spinal cord slice
Autore:
Yang, K; Feng, YP; Li, YQ;
Indirizzi:
Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China Fourth Mil Med Univ, KK Leung Brain Res Ctr, Xian 710032, Peoples R China Fourth Mil Med Univ Xian Peoples R China 710032 710032, Peoples R China
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 900, anno: 2001,
pagine: 320 - 323
SICI:
0006-8993(20010511)900:2<320:BIODRI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADULT-RAT; SYNAPTIC TRANSMISSION; PRESYNAPTIC INHIBITION; IN-VITRO; RECEPTORS; CAPSAICIN; AFFERENT; GLYCINE; HORN; TERMINALS;
Keywords:
baclofen; substantia gelatinosa; spinal cord; whole-cell voltage-clamp recording; inhibitory postsynaptic current; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Li, YQ Fourth Mil Med Univ, Dept Anat, Xian 710032, Peoples R China FourthMil Med Univ Xian Peoples R China 710032 , Peoples R China
Citazione:
K. Yang et al., "Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currentsin substantia gelatinosa neurons of rat spinal cord slice", BRAIN RES, 900(2), 2001, pp. 320-323

Abstract

We investigated the action of baclofen, an agonist for GABA(B) receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by A delta fibers. Baclofen (10 muM) reduced the amplitude of A delta fiber-evoked glycine receptor-mediated IPSCs to 20.9+/-3.0% (n = 13), and GABA(A) receptor-mediated IPSCs to18.6+/-3.4% (n = 12) of the controls, respectively. The results further suggest modulatory role of GABA(B) receptor in spinal dorsal hem. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:20:18