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Titolo:
Further evidence that extracellular serotonin in the rostral ventrolateralmedulla modulates 5-HT1A receptor-mediated attenuation of exercise presserreflex
Autore:
Chaiyakul, P; Reidman, D; Pilipovic, L; Maher, T; Ally, A;
Indirizzi:
Univ New England, Coll Osteopath Med, Dept Physiol, Biddeford, ME 04005 USA Univ New England Biddeford ME USA 04005 Physiol, Biddeford, ME 04005 USA Univ New England, Coll Osteopath Med, Dept Pharmacol, Biddeford, ME 04005 USA Univ New England Biddeford ME USA 04005 harmacol, Biddeford, ME 04005 USA Chulalongkorn Univ, Fac Pharmaceut Sci, Dept Pharmacol, Bangkok 10330, Thailand Chulalongkorn Univ Bangkok Thailand 10330 macol, Bangkok 10330, Thailand Massachusetts Coll Pharm & Hlth Sci, Dept Pharmacol, Boston, MA 02115 USA Massachusetts Coll Pharm & Hlth Sci Boston MA USA 02115 ton, MA 02115 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 900, anno: 2001,
pagine: 186 - 194
SICI:
0006-8993(20010511)900:2<186:FETESI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSCLE-CONTRACTION; MUSCULAR-CONTRACTION; BIOGENIC-AMINES; GLUTAMATE; RAT; NEURONS; RESPONSES; NUCLEUS; 5-HYDROXYTRYPTAMINE; ACTIVATION;
Keywords:
arterial blood pressure; heart rate; microdialysis; monoamine; glutamate; muscle afferent;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ally, A Loma Linda Univ, Sch Med, Ctr Perinatal Biol, Loma Linda, CA 92350USA Loma Linda Univ Loma Linda CA USA 92350 Loma Linda, CA 92350 USA
Citazione:
P. Chaiyakul et al., "Further evidence that extracellular serotonin in the rostral ventrolateralmedulla modulates 5-HT1A receptor-mediated attenuation of exercise presserreflex", BRAIN RES, 900(2), 2001, pp. 186-194

Abstract

We determined changes in extracellular levels of glutamate, serotonin (5-HT), norepinephrine (NE), and dopamine (DA) within rostral ventrolateral medulla (RVLM) during 5-HT1A-receptor stimulation-mediated inhibition of cardiovascular responses to static muscle contraction using anesthetized rats. In ten rats, muscle contraction significantly increased (P<0.01) mean arterial pressure (MAP) by 29+/-4 mmHg, heart rate (HR) by 25+/-3 bpm, and glutamate levels by 4.5+/-0.8 ng/5 <mu>l. Microdialysis of a 5-HT1A receptor agonist, 8-OH-DPAT (10 mM), into the RVLM for 30 min attenuated cardiovascular responses to muscle contraction and had no effect on glutamate levels. A subsequent administration of 10 mM WAY100635, a 5-HT1A antagonist, into the RVLM antagonized the attenuating effects of 8-OH-DPAT. In another ten rats, muscle contraction significantly increased (P<0.01) MAP and HR by 20+/-2 mmHg and 25+/-8 bpm, respectively. In addition, levels of 5-HT, NE, and DA inthe RVLM significantly increased (P<0.01) by 3.6+/-0.3, 3.2+/-0.3, and 3.3/-0.4 pg/10 mul, respectively. Administration of 8-OH-DPAT (10 mM) into the RVLM for 30 min attenuated cardiovascular responses to muscle contractionand had no effects on NE and DA levels. However, the drug significantly attenuated 5-HT levels following a muscle contraction. Microdialysis of 10 mMWAY100635 into the RVLM reversed both cardiovascular and 5-HT changes. These results suggest that stimulation of 5-HT1A-receptors within the RVLM attenuates cardiovascular responses to static exercise via a reduction of extracellular 5-HT concentration and most likely not through changes in glutamate. NE or DA levels. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:59:05