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Titolo:
Incorporation and distribution of strontium in bone
Autore:
Dahl, SG; Allain, P; Marie, PJ; Mauras, Y; Boivin, G; Ammann, P; Tsouderos, Y; Delmas, PD; Christiansen, C;
Indirizzi:
Univ Tromso, Fac Med, Dept Pharmacol, N-9037 Tromso, Norway Univ Tromso Tromso Norway N-9037 , Dept Pharmacol, N-9037 Tromso, Norway CHU Angers, Lab Pharmacol & Toxicol, Angers, France CHU Angers Angers France ngers, Lab Pharmacol & Toxicol, Angers, France CNRS, Lariboisiere Hosp, INSERM, U349, Paris, France CNRS Paris FranceCNRS, Lariboisiere Hosp, INSERM, U349, Paris, France Fac Med R Laennec, INSERM, U403, Lyon, France Fac Med R Laennec Lyon France Med R Laennec, INSERM, U403, Lyon, France Univ Geneva, Hop Cantonal, Div Malad Osseuses, Dept Med Interne, CH-1211 Geneva, Switzerland Univ Geneva Geneva Switzerland CH-1211 erne, CH-1211 Geneva, Switzerland Inst Rech Int Servier, F-92415 Courbevoie, France Inst Rech Int Servier Courbevoie France F-92415 92415 Courbevoie, France Ctr Clin & Basic Res, Ballerup, Denmark Ctr Clin & Basic Res Ballerup Denmark in & Basic Res, Ballerup, Denmark
Titolo Testata:
BONE
fascicolo: 4, volume: 28, anno: 2001,
pagine: 446 - 453
SICI:
8756-3282(200104)28:4<446:IADOSI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL OSTEOPOROSIS; CALCIUM-METABOLISM; MINERAL DENSITY; ILIAC BONE; RATS; FLUORIDE; RESORPTION; ARTHRITIS; TURNOVER; SKELETON;
Keywords:
strontium; bone formation; mineralization; osteoporosis; gender difference; elimination rate;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Dahl, SG Univ Tromso, Fac Med, Dept Pharmacol, N-9037 Tromso, Norway Univ Tromso Tromso Norway N-9037 armacol, N-9037 Tromso, Norway
Citazione:
S.G. Dahl et al., "Incorporation and distribution of strontium in bone", BONE, 28(4), 2001, pp. 446-453

Abstract

The distribution and incorporation of strontium into bone has been examined in rats, monkeys, and humans after oral administration of strontium (either strontium chloride or strontium ranelate), After repeated administrationfor a sufficient period of time (at least 4 weeks in rats), strontium incorporation into bone reaches a plateau level, This plateau appears to be lower in females than in males due to a difference in the absorption process. Steady-state plasma strontium levels are reached more rapidly than in bones, and within 10 days in the rat. The strontium levels in bone vary according to the anatomical site. However, strontium Levels at different skeletal sites are strongly correlated, and the strontium content of the lumbar vertebra may be estimated from iliac crest bone biopsies in monkeys. The strontium levels in bone also vary according to the bone structure and higher amounts of strontium are found in cancellous bone than in cortical bone. Furthermore, at the crystal level, higher concentrations of strontium are observed in newly formed bone than in old bone. After withdrawal of treatment, thebone strontium content rapidly decreases in monkeys. The relatively high clearance rate of strontium from bone can be explained by the mechanisms of its incorporation. Strontium is mainly incorporated by exchange onto the crystal surface, In new bone, only a few strontium atoms may be incorporated into the crystal by ionic substitution of calcium. After treatment withdrawal, strontium exchanged onto the crystal is rapidly eliminated, which leadsto a rapid decrease in total bone strontium levels, In summary, incorporation of strontium into bone, mainly by exchange onto the crystal surface, isdependent on the duration of treatment, dose, gender, and skeletal site. Nevertheless, bone strontium content is highly correlated with plasma strontium levels and, in bone, between the different skeletal sites. (Bone 28: 446-453; 2001) (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 15:13:50