Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Targeting of hormone replacement therapy immediately after menopause
Autore:
Johnell, O; Kanis, JA; Oden, A; Redlund-Johnell, I; Hasserius, R; Sernbo, I; Caulin, F;
Indirizzi:
Univ Sheffield, Sch Med, WHO Collaborating Ctr, Ctr Metab Bone Dis, Sheffield S10 2RX, S Yorkshire, England Univ Sheffield Sheffield S Yorkshire England S10 2RX S Yorkshire, England Malmo Gen Hosp, Dept Orthopaed, S-21401 Malmo, Sweden Malmo Gen Hosp Malmo Sweden S-21401 ept Orthopaed, S-21401 Malmo, Sweden FC Consulting, Paris, France FC Consulting Paris FranceFC Consulting, Paris, France
Titolo Testata:
BONE
fascicolo: 4, volume: 28, anno: 2001,
pagine: 440 - 445
SICI:
8756-3282(200104)28:4<440:TOHRTI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MINERAL DENSITY; CORONARY HEART-DISEASE; POSTMENOPAUSAL WOMEN; HIP FRACTURE; TRANSDERMAL 17-BETA-ESTRADIOL; OSTEOPOROSIS; PREVENTION; ESTROGEN; TRIAL; EFFICACY;
Keywords:
hormone replacement therapy; fractures; number needed to treat (NNT); bone material density; offset of effect;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Kanis, JA Univ Sheffield, Sch Med, WHO Collaborating Ctr, Ctr Metab Bone Dis, Beach Hill Rd, Sheffield S10 2RX, S Yorkshire, England Univ Sheffield Beach Hill Rd Sheffield S Yorkshire England S10 2RX
Citazione:
O. Johnell et al., "Targeting of hormone replacement therapy immediately after menopause", BONE, 28(4), 2001, pp. 440-445

Abstract

The aim of this study was to model the effect of short (3-year) treatmentswith hormone replacement therapy (HRT) at the time of menopause on the risk of osteoporotic fracture, and to assess the impact of strategies to target high-risk individuals. From the relationship between bone mineral density(BMD) and fracture risk, treatment that increased bone mineral density at the hip by 6% over untreated women would save 35 vertebral, 62 hip, 13 proximal humeral, and 16 forearm fractures per 1000 women. The number needed totreat (NNT) to prevent one of these fractures was 8, The NNT fell modestlyby targeting HRT to women with low bone mass or osteoporosis (NNT 6 and 5,respectively), The gains in fractures saved from targeting women with low bone mass or osteoporosis were offset by the requirement for assessment by BMD, Changes in the assumptions about the efficacy of HRT had a modest impact on fractures saved compared with the effect of changing assumptions concerning the offset of effect when treatment was stopped. We conclude that comparatively short courses of HRT might be effectively offered to all suitable women at menopause provided that the effects on bone persist when treatment is stopped. (Bone 28:440-445; 2001) (C) 2001 by Elsevier Science Inc, All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:24:22