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Titolo:
Differential requirement for the transcription factor PU.1 in the generation of natural killer cells versus B and T cells
Autore:
Colucci, F; Samson, SI; DeKoter, RP; Lantz, O; Singh, H; Di Santo, JP;
Indirizzi:
Inst Pasteur, Dept Immunol, Lab Cytokines & Lymphoid Dev, F-75015 Paris, France Inst Pasteur Paris France F-75015 & Lymphoid Dev, F-75015 Paris, France Univ Chicago, Howard Hughes Med Inst, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 Hughes Med Inst, Chicago, IL 60637 USA Hop Necker Enfants Malad, INSERM, U25, Paris, France Hop Necker Enfants Malad Paris France Malad, INSERM, U25, Paris, France
Titolo Testata:
BLOOD
fascicolo: 9, volume: 97, anno: 2001,
pagine: 2625 - 2632
SICI:
0006-4971(20010501)97:9<2625:DRFTTF>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-GAMMA CHAIN; MYELOID PROGENITOR; DENDRITIC CELLS; TYROSINE KINASE; DEFICIENT MICE; MOUSE MODEL; BONE-MARROW; IDENTIFICATION; GENE; PROLIFERATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Colucci, F Inst Pasteur, Dept Immunol, Lab Cytokines & Lymphoid Dev, 25-28Rue Dr Roux, F-75015 Paris, France Inst Pasteur 25-28 Rue Dr Roux Paris France F-75015 is, France
Citazione:
F. Colucci et al., "Differential requirement for the transcription factor PU.1 in the generation of natural killer cells versus B and T cells", BLOOD, 97(9), 2001, pp. 2625-2632

Abstract

PU.1 is a member of the Ets family of transcription factors required for the development of various lymphoid and myeloid cell lineages, but its role in natural killer (NK) cell development is not known. The study shows that PU.1 is expressed in NK cells and that, on cell transfer into alymphoid Rag2/gammac(-/-) mice, hematopoietic progenitors of PU.1(-/-) fetal liver cells could generate functional NK cells but not B or T cells. Nevertheless, the numbers of bone marrow NK cell precursors and splenic mature NK cells were reduced compared to controls. Moreover, PU.1(-/-) NK cells displayed reduced expression of the receptors for stem cell factor and interleukin (IL)-7, suggesting a nonredundant role for PU.1 in regulating the expression of these cytokine receptor genes during NK cell development. PU.1(-/-) NK cellsalso showed defective expression of inhibitory and activating members of the Ly49 family and failed to proliferate in response to IL-2 and IL-12. Thus, despite the less stringent requirement for PU.1 in NK cell development compared to B and T cells, PU.1 regulates NK cell differentiation and homeostasis. (Blood, 2001;97:2625-2632) (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:07:24