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Titolo:
Serum lithium levels and the outcome of maintenance therapy of bipolar disorder
Autore:
Hopkins, HS; Gelenberg, AJ;
Indirizzi:
Univ Arizona, Ctr Hlth Sci, Dept Psychiat, Tucson, AZ 85748 USA Univ Arizona Tucson AZ USA 85748 Sci, Dept Psychiat, Tucson, AZ 85748 USA Arizona Editors Writing & Editing Specialists, Tucson, AZ 85748 USA Arizona Editors Writing & Editing Specialists Tucson AZ USA 85748 748 USA
Titolo Testata:
BIPOLAR DISORDERS
fascicolo: 3, volume: 2, anno: 2000,
parte:, 1
pagine: 174 - 179
SICI:
1398-5647(200009)2:3<174:SLLATO>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-DISORDER; PROPHYLAXIS; STANDARD;
Keywords:
bipolar depression; bipolar disorder; lithium; lithium toxicity; mania; serum lithium levels;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Gelenberg, AJ Univ Arizona, Ctr Hlth Sci, Dept Psychiat, 1501 N Campbell Ave, Tucson, AZ85748 USA Univ Arizona 1501 N Campbell Ave Tucson AZ USA 85748 748 USA
Citazione:
H.S. Hopkins e A.J. Gelenberg, "Serum lithium levels and the outcome of maintenance therapy of bipolar disorder", BIPOL DIS, 2(3), 2000, pp. 174-179

Abstract

A literature review was conducted to locate studies that compared different serum lithium levels in the long-term treatment of patients with bipolar disorder and articles about factors that may affect serum lithium levels, Patients with bipolar disorder on long-term treatment with lithium are typically maintained at serum lithium concentrations between 0.6 and 1.0 mEq/L. Although there are individual exceptions, serum lithium levels below 0.6 mEq/L have been shown in controlled clinical trials to be less effective in preventing relapses than levels within this range, whereas levels much above1.2 mEq/L can lead to toxicity. Differences in efficacy between levels within the accepted range have not been established. However, higher levels are associated with greater side effects, which can lead to poor compliance. Interindividual variation in pharmacokinetics and pharmacodynamics, as wellas such external factors as diet and concomitant medications, can affect serum lithium levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:11:48