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Titolo:
Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones
Autore:
Xia, Y; Yang, ZY; Hour, MJ; Kuo, SC; Xia, P; Bastow, KF; Nakanishi, Y; Nampoothiri, P; Hackl, T; Hamel, E; Lee, KH;
Indirizzi:
Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA Univ NCarolina Chapel Hill NC USA 27599 d Lab, Chapel Hill, NC 27599 USA China Med Coll, Taichung, Taiwan China Med Coll Taichung TaiwanChina Med Coll, Taichung, Taiwan NCI, Frederick Canc Res & Dev Ctr, Screening Technol Branch, Dev TherapeutProgram,Div Canc Treatment & Diag, Frederick, MD 21702 USA NCI Frederick MD USA 21702 Canc Treatment & Diag, Frederick, MD 21702 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 9, volume: 11, anno: 2001,
pagine: 1193 - 1196
SICI:
0960-894X(20010507)11:9<1193:AAP2SA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUBULIN POLYMERIZATION; CYTOTOXICITY; 2-PHENYL-4-QUINOLONES; INHIBITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, KH Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA Univ N Carolina Chapel Hill NC USA 27599 hapel Hill, NC 27599 USA
Citazione:
Y. Xia et al., "Antitumor agents. Part 204: Synthesis and biological evaluation of substituted 2-aryl quinazolinones", BIOORG MED, 11(9), 2001, pp. 1193-1196

Abstract

A series of 2 ' ,3 ' ,4 ' ,6,7-substituted 2-aryl quinazolinones were synthesized and evaluated for biological activity. Among them, 17 displayed significant growth inhibitory action against a panel of tumor cell lines. Compound 17 was also a potent inhibitor of tubulin polymerization. Compounds 8-10 displayed selective activity against P-gp-expressing epidermoid carcinoma of the nasopharynx. (C) 2001 Elsevier Science Ltd. all rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:24:01