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Titolo:
Synthesis and evaluation of efavirenz (Sustiva (TM)) analogues as HIV-1 reverse transcriptase inhibitors: Replacement of the cyclopropylacetylene side chain
Autore:
Cocuzza, AJ; Chidester, DR; Cordova, BC; Jeffrey, S; Parsons, RL; Bacheler, LT; Erickson-Viitanen, S; Trainor, GL; Ko, SS;
Indirizzi:
DuPont Pharmaceut Co, Expt Stn, Wilmington, DE 19880 USA DuPont PharmaceutCo Wilmington DE USA 19880 tn, Wilmington, DE 19880 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 9, volume: 11, anno: 2001,
pagine: 1177 - 1179
SICI:
0960-894X(20010507)11:9<1177:SAEOE(>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Cocuzza, AJ DuPont Pharmaceut Co, Expt Stn, E336-141,POB 80336, Wilmington, DE 19880 USA DuPont Pharmaceut Co E336-141,POB 80336 Wilmington DE USA 19880
Citazione:
A.J. Cocuzza et al., "Synthesis and evaluation of efavirenz (Sustiva (TM)) analogues as HIV-1 reverse transcriptase inhibitors: Replacement of the cyclopropylacetylene side chain", BIOORG MED, 11(9), 2001, pp. 1177-1179

Abstract

Two series of efavirenz analogues have been developed: one in which the cyclopropane ring has been replaced by small heterocycles and another in which the entire acetylenic side chain has been replaced by alkyloxy groups. Several members of both series show equivalent potency to efavirenz against both wild-type virus and the key K103N mutant. (C) 2001 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:12:58