Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Binding of dimeric aminoglycosides to the HIV-1 Rev responsive element (RRE) RNA construct
Autore:
Tok, JBH; Dunn, LJ; Jean, RCD;
Indirizzi:
Indiana Univ Purdue Univ, Dept Chem, Ft Wayne, IN 46805 USA Indiana Univ Purdue Univ Ft Wayne IN USA 46805 em, Ft Wayne, IN 46805 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 9, volume: 11, anno: 2001,
pagine: 1127 - 1131
SICI:
0960-894X(20010507)11:9<1127:BODATT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
16S RIBOSOMAL-RNA; HAMMERHEAD RIBOZYME; ALPHA-HELIX; RECOGNITION; PEPTIDE; ANTIBIOTICS; INHIBITION; SPECIFICITY; NEOMYCIN; COMPLEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Tok, JBH CUNY York Coll, Dept Chem, Jamaica, NY 11451 USA CUNY York Coll Jamaica NY USA 11451 Chem, Jamaica, NY 11451 USA
Citazione:
J.B.H. Tok et al., "Binding of dimeric aminoglycosides to the HIV-1 Rev responsive element (RRE) RNA construct", BIOORG MED, 11(9), 2001, pp. 1127-1131

Abstract

Through a series of elegant fluorescence measurements: particularly through stopped-flow kinetic measurements, it was recently demonstrated that aminoglycoside antibiotics are able to bind to the HIV-1 Rev responsive element(RRE) RNA construct in more than a 1:1 stoichiometry (Lacourciere, K. A.; Stivers, J. T.; Marine; J. P. Biochemistry 2000, 9, 5630). Here, we presentthe binding study results of dimeric neomycin Ligands through fluorescenceanisotropy studies, to the HIV-I RRE RNA construct. The dimeric neomycin molecules are observed to be able to bind the HIV-1 RRE RNA construct approximately 17-fold higher when compared to the monomeric neomycin, lending evidence that there are indeed two or more neomycin binding sites within the HIV-1 RRE construct. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 06:20:54