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Titolo:
Event-related brain potentials (ERPs) in schizophrenia for tonal and phonetic oddball tasks
Autore:
Kayser, J; Bruder, GE; Tenke, CE; Stuart, BK; Amador, XF; Gorman, JM;
Indirizzi:
New York State Psychiat Inst, Dept Biopsychol, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA New York State Psychiat Inst, Dept Clin Psychobiol, New York, NY 10032 USANew York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ, Coll Phys & Surg, Dept Psychiat, New York, NY 10027 USA Columbia Univ New York NY USA 10027 Dept Psychiat, New York, NY 10027 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 10, volume: 49, anno: 2001,
pagine: 832 - 847
SICI:
0006-3223(20010515)49:10<832:EBP(IS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRINCIPAL COMPONENT ANALYSIS; P300 SUBCOMPONENT ABNORMALITIES; LEFT TEMPORAL-LOBE; MISMATCH NEGATIVITY; EMOTIONAL STIMULI; CYCLOID PSYCHOSIS; AUDITORY-STIMULI; AMPLITUDE; VARIANCE; MISALLOCATION;
Keywords:
schizophrenia; event-related potentials (ERPs); N2/P3 complex; hemispheric asymmetries; tonal/phonetic oddball tasks; principal components analysis (PCA);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
82
Recensione:
Indirizzi per estratti:
Indirizzo: Kayser, J New York State Psychiat Inst, Dept Biopsychol, Unit 50,1051 Riverside Dr, New York, NY 10032 USA New York State Psychiat Inst Unit 50,1051 Riverside Dr New York NY USA 10032
Citazione:
J. Kayser et al., "Event-related brain potentials (ERPs) in schizophrenia for tonal and phonetic oddball tasks", BIOL PSYCHI, 49(10), 2001, pp. 832-847

Abstract

Background: Prior studies ruing simple target detection ("oddball") tasks with pure tones have reported asymmetric reduction of the P3 event-related potential (ERP). This study investigated the time course and topography of ERPs recorded during both tonal and phonetic oddball tasks. Methods: Event-related potentials of 66 patients (14 unmedicated) diagnosed with schizophrenia (n = 46) or schizoaffective disorder (n = 20) and 32 healthy adults were recorded from 30 scalp electrodes dilling tnto oddball task using consonant-vowel syllables or complex tones. Overlapping ERP components were identified and measured by covariance-based principal componentsanalysis. Results: Schizophrenic patients showed marked, task-independent reductionsof early, negative, potentials (N1, N2) brit not reduced P3 amplitude ol abnormal P3 asymmetry. Task-related hemispheric asymmetries of the N2/P3 complex were similar in healthy adults and schizophrenic patients. Poorer taskperformance in patients was related to ERP amplitudes, but could not account for reductions of early, negafivifies. Conclusions: The findings suggest that both patients and control subjects activated lateralized cortical networks required for pitch (right frontotemporal) and phoneme (left parietotemporal) discrimination. Task-independent reductions of negativities between 80 and 280 msec after stimulus onset suggest a deficit of automatic stimulus classification in schizophrenia, whichmay be partly compensated by later effortful processing.

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Documento generato il 02/12/20 alle ore 18:20:27