Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia
Autore:
Lawrie, SM; Whalley, HC; Abukmeil, SS; Kestelman, JN; Donnelly, L; Miller, P; Best, JJK; Owens, DGC; Johnstone, EC;
Indirizzi:
Univ Edinburgh, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH10 5HF idlothian, Scotland
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 10, volume: 49, anno: 2001,
pagine: 811 - 823
SICI:
0006-3223(20010515)49:10<811:BSGLAP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; EDINBURGH HIGH-RISK; GRAY-MATTER VOLUME; CHILDHOOD-ONSET SCHIZOPHRENIA; MAGNETIC-RESONANCE IMAGES; CAUDATE NUCLEI VOLUMES; LEFT TEMPORAL-LOBE; HIPPOCAMPAL VOLUME; PREFRONTAL CORTEX; YOUNG-PEOPLE;
Keywords:
brain; MRI; high risk; schizophrenia; genetic liability; psychotic symptoms;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
73
Recensione:
Indirizzi per estratti:
Indirizzo: Lawrie, SM Univ Edinburgh, Royal Edinburgh Hosp, Dept Psychiat, Kennedy Tower, Edinburgh EH10 5HF, Midlothian, Scotland Univ Edinburgh Kennedy Tower Edinburgh Midlothian Scotland EH10 5HF
Citazione:
S.M. Lawrie et al., "Brain structure, genetic liability, and psychotic symptoms in subjects at high risk of developing schizophrenia", BIOL PSYCHI, 49(10), 2001, pp. 811-823

Abstract

Background: Structural magnetic resonance imaging (MRI) of the brain in patients with schizophrenia has consistently demonstrated several abnormalities. These are thought to be neurodevelopmental in origin, as they have alsobeen described in first episode cases, although there may be a progressivecomponent. It is not known at which point in development these abnormalities are evident, nor to what extent they are genetically or environmentally mediated. Methods: One hundred forty-seven high-risk subjects (with at least two affected first or second degree relatives), 34 patients in their first episode, and 36 healthy control subjects received an MRI scan covering the whole brain. After inhomogeneity correction, regions of interest were traced by three group-blind raters with good inter-rater reliability. Regional brain volumes were related to measures of genetic liability to schizophrenia and topsychotic symptoms elicited at structured psychiatric interviews. Results: High-risk subjects had statistically significantly reduced mean volumes of the left and right amygdalo-hippocampus and thalamus, as comparedto healthy control subjects. They also had bilaterally larger amygdalo-hippocampi and bilaterally smaller lenticular nuclei than the schizophrenics. High-risk subjects with symptoms had smaller brains than those without. Thevolumes of the prefrontal lobes and the thalamus were the only consistent associates of genetic liability. Conclusions: Subjects at high risk of developing schizophrenia have abnormalities of brain structure similar to but not identical to those found in schizophrenia. Our results suggest that some structural abnormalities are genetic trait or vulnerability markers, others are environmentally mediated, and that the development of symptoms is associated with a third overlappinggroup of structural changes. Particular risk factors for schizophrenia mayinteract at discrete time points of neurodevelopment with different effects on specific brain regions and may represent relatively distinct disease processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:32:56