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Titolo:
Effects of high ELF magnetic fields on enzyme-catalyzed DNA and RNA synthesis in vitro and on a cell-free DNA mismatch repair
Autore:
Harada, S; Yamada, S; Kuramata, O; Gunji, Y; Kawasaki, M; Miyakawa, T; Yonekura, H; Sakurai, S; Bessho, K; Hosono, R; Yamamoto, H;
Indirizzi:
Kanazawa Univ, Fac Engn, Lab Magnet Field Control & Applicat, Kanazawa, Ishikawa 9208667, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208667 wa, Ishikawa 9208667, Japan Kanazawa Univ, Sch Med, Ctr Biomed Res & Educ, Kanazawa, Ishikawa 9208667,Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208667 awa, Ishikawa 9208667,Japan Kanazawa Univ, Sch Med, Dept Biochem, Kanazawa, Ishikawa 9208667, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208667 wa, Ishikawa 9208667, Japan Kanazawa Univ, Fac Med, Dept Phys Informat, Kanazawa, Ishikawa 9208667, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208667 wa, Ishikawa 9208667, Japan
Titolo Testata:
BIOELECTROMAGNETICS
fascicolo: 4, volume: 22, anno: 2001,
pagine: 260 - 266
SICI:
0197-8462(200105)22:4<260:EOHEMF>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROMAGNETIC-FIELDS; CHILDHOOD-CANCER; COLON-CANCER; EXPOSURE; EXTRACTS;
Keywords:
60 Hz magnetic fields; in vitro enzyme-catalyzed reaction; cell extracts; DNA polymerase; RNA polymerase; mutS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Yamada, S Kanazawa Univ, Fac Engn, Lab Magnet Field Control & Applicat, 2-40-20 Kodatsuno, Kanazawa, Ishikawa 9208667, Japan Kanazawa Univ 2-40-20 Kodatsuno Kanazawa Ishikawa Japan 9208667
Citazione:
S. Harada et al., "Effects of high ELF magnetic fields on enzyme-catalyzed DNA and RNA synthesis in vitro and on a cell-free DNA mismatch repair", BIOELECTROM, 22(4), 2001, pp. 260-266

Abstract

Environmental electromagnetic fields have been implicated in human cancers. We examined whether high extremely low frequency (ELF) AC magnetic fieldscould affect DNA synthesis, transcription or repair, using in vitro model systems with defined sequences. The rate and fidelity of DNA polymerase catalyzed DNA synthesis, as well as of RNA polymerase catalyzed RNA synthesis,were not statistically significantly affected by 60 Hz 0.25-0.5 Tesla magnetic fields. The efficiency of mutS dependent mismatch repair with human cell extracts was also not affected by the magnetic field exposure. The results suggest that the core processes related to the transmission of genetic information are stable under high ELF magnetic fields. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 29/03/20 alle ore 09:22:30