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Titolo:
Targeting tumour necrosis factor in the treatment of rheumatoid arthritis
Autore:
Pearce, GJ; Chikanza, IC;
Indirizzi:
Univ London Queen Mary & Westfield Coll, Bone & Joint Res Unit, Sch Med & Dent, St Bartholowmews & Royal London Hosp, London EC1M 6BQ, England Univ London Queen Mary & Westfield Coll London England EC1M 6BQ England Univ London Queen Mary & Westfield Coll, St Bartholowmews & Royal London Hosp, Dept Rheumatol, Sch Med & Dent, London EC1M 6BQ, England Univ London Queen Mary & Westfield Coll London England EC1M 6BQ England
Titolo Testata:
BIODRUGS
fascicolo: 3, volume: 15, anno: 2001,
pagine: 139 - 149
SICI:
1173-8804(2001)15:3<139:TTNFIT>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHIMERIC MONOCLONAL-ANTIBODY; COLLAGEN-INDUCED ARTHRITIS; INTERLEUKIN-1 RECEPTOR ANTAGONIST; FACTOR-ALPHA PRODUCTION; FACTOR BINDING-PROTEIN; IN-VIVO BLOCKADE; B-CELL LINES; TNF-ALPHA; RECEIVING METHOTREXATE; SYNOVIAL-MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
79
Recensione:
Indirizzi per estratti:
Indirizzo: Chikanza, IC Univ London Queen Mary & Westfield Coll, Bone & Joint Res Unit, Sch Med & Dent, St Bartholowmews & Royal London Hosp, Charterhouse Sq, London EC1M 6BQ, England Univ London Queen Mary & Westfield Coll Charterhouse Sq London England EC1M 6BQ
Citazione:
G.J. Pearce e I.C. Chikanza, "Targeting tumour necrosis factor in the treatment of rheumatoid arthritis", BIODRUGS, 15(3), 2001, pp. 139-149

Abstract

Inflammation in rheumatoid arthritis (RA) is associated with an imbalance between pro- and anti-inflammatory factors, which leads to a persistent chronic inflammatory state in the joint. Molecular studies of the physiology of the inflammatory response have identified a hierarchy of cytokine activities. The identification of this hierarchy has provided new potential therapeutic targets for the treatment of RA. At present the majority of new therapeutic agents have been developed to neutralise the activity of tumour necrosis factor-alpha (TNF alpha), a cytokine at the top OF the inflammatory cascade. These agents consist of recombinant proteins that bind and neutralise TNF alpha, and they are effective in the treatment of inflammation in RA. In this review we discuss the rationale behind targeting TNF alpha, the various recombinant proteins that have been used, their clinical effectiveness, the possible adverse effects of these agents and the development of new chemical inhibitors of TNF alpha synthesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:03:06