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Titolo:
Evaluation of esterified hyaluronic acid as middle ear-packing material
Autore:
Li, G; Feghali, JG; Dinces, E; McElveen, J; Van De Water, TR;
Indirizzi:
Albert Einstein Coll Med, Dept Otolaryngol, Kennedy Ctr, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 nedy Ctr, Bronx, NY 10461 USA Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Neurosci, Bronx, NY 10461 USA Montefiore Med Ctr, Dept Otolaryngol, Bronx, NY 10467 USA Montefiore Med Ctr Bronx NY USA 10467 pt Otolaryngol, Bronx, NY 10467 USA Beth Israel Med Ctr, Dept Otolaryngol, New York, NY USA Beth Israel Med Ctr New York NY USA , Dept Otolaryngol, New York, NY USA Carolina Ear & Hearing Clin, Raleigh, NC USA Carolina Ear & Hearing Clin Raleigh NC USA Hearing Clin, Raleigh, NC USA
Titolo Testata:
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
fascicolo: 5, volume: 127, anno: 2001,
pagine: 534 - 539
SICI:
0886-4470(200105)127:5<534:EOEHAA>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
10
Recensione:
Indirizzi per estratti:
Indirizzo: Van De Water, TR Albert Einstein Coll Med, Dept Otolaryngol, Kennedy Ctr, 1410 Pelham Pkwy S,Room 302, Bronx, NY 10461 USA Albert Einstein Coll Med 1410 Pelham Pkwy S,Room 302 Bronx NY USA 10461
Citazione:
G. Li et al., "Evaluation of esterified hyaluronic acid as middle ear-packing material", ARCH OTOLAR, 127(5), 2001, pp. 534-539

Abstract

Objective: To evaluate the efficacy of esterified hyaluronic acid (MeroGel) as a middle ear (ME)-packing material. Design: Randomized controlled trial. Material: Twenty-four guinea pigs. Intervention: Group 1,MeroGel-treated animals (n= 10), bilateral wounding of ME mucosa with 5 of the animals receiving the MeroGel packing in the left ME and 5 of the animals receiving MeroGel in the right ME; group 2, absorbable gelatin sponge-treated animals (n= 10), with the same experimental protocol as in group 1 except that the absorbable gelatin sponge was the packing material; group 3, untreated animals (n=4), unilateral wounding of the left ME mucosa in 2 animals and in 2 animals in the right ME. with no packing material. Auditory brainstem recordings were performed for all groups before the ME operation and 5 days and 6 weeks after the operation. Results: Auditory brainstem response recordings at postoperative day 5 showed that all ears with ME packing had hearing losses in the frequency rangeof 500 to 4000 Hz, The recovery of hearing acuity at postoperative week 6 was significantly better in group 1 (MeroGel-treated) guinea pigs compared with group 2 (the absorbable gelatin sponge-treated) animals. In group 2 animals, 20% of the packing material remained in the ME cavities and new boneformation was observed, while in group 1 animals, there was less packing material in the ME and no formation of new bone. Conclusions: MeroGel is a nonototoxic packing material with a high level of biocompatibility for ME mucosa; it is an effective supportive material following ME surgery and is easily expelled from the ME cavity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 15:30:31